PEX5 and PRDX5

Number of citations of the paper that reports this interaction (PMID 20178365)
7

Data Source:
BioGRID (unspecified method)

		PEX5	PRDX5
Gene Name		peroxisomal biogenesis factor 5	peroxiredoxin 5
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein Complex	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Protein C-terminus Binding Enzyme Binding Small GTPase Binding Protein N-terminus Binding	RNA Polymerase III Regulatory Region DNA Binding Peroxidase Activity Receptor Binding Antioxidant Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Dimerization Activity Peroxiredoxin Activity Peroxynitrite Reductase Activity
	Biological Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Protein Tetramerization Negative Regulation Of Protein Homotetramerization	Response To Reactive Oxygen Species Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Oxidoreductase Activity Oxidation-reduction Process Regulation Of Apoptosis Involved In Tissue Homeostasis NADPH Oxidation Reactive Nitrogen Species Metabolic Process
Pathways
Drugs			Auranofin Diminazene Benzoic Acid
Diseases
GWAS		IgG glycosylation ( 23382691)	Alopecia areata ( 20596022) Crohn's disease ( 21102463) Sarcoidosis ( 22837380)
Protein-Protein Interactions		68 interactors: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EP400NL EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PECR PEX10 PEX12 PEX13 PEX14 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP9X ZNF772	3 interactors: APP CCDC90B PEX5
Entrez ID		5830	25824
HPRD ID		02684	05958
Ensembl ID		ENSG00000139197	ENSG00000126432
Uniprot IDs		B4DR50 B4E0T2 P50542	P30044
PDB IDs		1FCH 2C0L 2C0M 2J9Q 2W84 3R9A	1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG
Enriched GO Terms of Interacting Partners?		Carboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Fatty Acid Oxidation Catabolic Process Lipid Oxidation Fatty Acid Catabolic Process Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Modification Cellular Lipid Catabolic Process Lipid Catabolic Process Peroxisome Organization Oxidation-reduction Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Protein Import Into Peroxisome Matrix Cellular Metabolic Process Acyl-CoA Metabolic Process Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Bile Acid Biosynthetic Process Intracellular Protein Transmembrane Transport Cofactor Metabolic Process Protein Transmembrane Transport Lipid Biosynthetic Process Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Sulfur Compound Metabolic Process Glyoxylate Metabolic Process Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Steroid Biosynthetic Process Protein Targeting Telomere Assembly Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Steroid Metabolic Process Cellular Amino Acid Catabolic Process Long-chain Fatty Acid Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Cellular Process Dicarboxylic Acid Catabolic Process Coenzyme A Catabolic Process	Regulation Of Multicellular Organism Growth Neuromuscular Process Regulation Of Developmental Growth Negative Regulation Of Protein Homotetramerization Synaptic Growth At Neuromuscular Junction Protein Import Into Peroxisome Matrix, Translocation Collateral Sprouting In Absence Of Injury Protein Import Into Peroxisome Matrix, Docking Forebrain Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Homooligomerization Axon Choice Point Recognition Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Regulation Of Growth Neuron Remodeling Negative Regulation Of Protein Oligomerization Brain Development Protein Import Into Peroxisome Matrix Head Development Cellular Copper Ion Homeostasis Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Very Long-chain Fatty Acid Metabolic Process Neuron Differentiation Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Neurological System Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Lipid Metabolic Process RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle
Tagcloud ?		behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled	accelerates autoreactive cba draining gpx2 gpx4 gpx7 h2 imbalances immunoregulatory iodide isat looked microscopically nai peroxidases peroxiredoxins plausible prdx1 prdx2 sat thioredoxin thyrocytes thyroiditis txn1 ucp2 ucp3 uncoupling upregulates
Tagcloud (Difference) ?		behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled	accelerates autoreactive cba draining gpx2 gpx4 gpx7 h2 imbalances immunoregulatory iodide isat looked microscopically nai peroxidases peroxiredoxins plausible prdx1 prdx2 sat thioredoxin thyrocytes thyroiditis txn1 ucp2 ucp3 uncoupling upregulates
Tagcloud (Intersection) ?