PXN and DGUOK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PXN	DGUOK
Gene Name		paxillin	deoxyguanosine kinase
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Nucleus Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding	Deoxyguanosine Kinase Activity ATP Binding Nucleoside Kinase Activity
	Biological Process	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway	Purine Nucleobase Metabolic Process Protein Phosphorylation Guanosine Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Neuron Projection Development Purine-containing Compound Salvage Small Molecule Metabolic Process DGTP Metabolic Process Purine Deoxyribonucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Purine metabolism Metabolism of nucleotides Purine salvage
Drugs
Diseases
GWAS			Dialysis-related mortality ( 21546767) Systemic lupus erythematosus ( 23273568)
Protein-Protein Interactions		73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1	3 interactors: APP LIG4 PXN
Entrez ID		5829	1716
HPRD ID		03937	03273
Ensembl ID		ENSG00000089159	ENSG00000114956
Uniprot IDs		E7EMK8 F5GZ78 P49023	D6W5I0 E5KSL5 E5KSL6 Q16854
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN	2OCP
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion	Neuron Apoptotic Process Neuron Death DNA Ligation Involved In DNA Recombination Cell Adhesion Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cell Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Pro-B Cell Differentiation Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Response To Oxidative Stress Response To Radiation Neuron Remodeling Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Lymphoid Progenitor Cell Differentiation DNA Ligation Signal Complex Assembly Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Cellular Copper Ion Homeostasis Cell Activation Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Growth Hormone Receptor Signaling Pathway Response To Stress Regulation Of Kinase Activity Cellular Response To Growth Hormone Stimulus Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Neuron Maturation MRNA Polyadenylation Focal Adhesion Assembly Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	candidate center cholestasis clarify copy deoxyguanosine depletion failure hepatocerebral histopathologic infantile infants leukocytes liver manifested mitochondrial mpv17 muscle mutations pathogenic polymerase progressive radiologic referred representing sequenced skeletal suspected tertiary
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	candidate center cholestasis clarify copy deoxyguanosine depletion failure hepatocerebral histopathologic infantile infants leukocytes liver manifested mitochondrial mpv17 muscle mutations pathogenic polymerase progressive radiologic referred representing sequenced skeletal suspected tertiary
Tagcloud (Intersection) ?