DGUOK and LIG4

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		DGUOK	LIG4
Gene Name		deoxyguanosine kinase	ligase IV, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol	Condensed Chromosome Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex
	Molecular Function	Deoxyguanosine Kinase Activity ATP Binding Nucleoside Kinase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process Protein Phosphorylation Guanosine Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Negative Regulation Of Neuron Projection Development Purine-containing Compound Salvage Small Molecule Metabolic Process DGTP Metabolic Process Purine Deoxyribonucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Ligation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Proliferation Response To X-ray Response To Gamma Radiation Viral Process T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion DNA Biosynthetic Process Establishment Of Integrated Proviral Latency
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage	HIV Life Cycle Nonhomologous End-joining (NHEJ) HIV Infection Integration of provirus Double-Strand Break Repair 2-LTR circle formation Early Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Systemic lupus erythematosus ( 23273568)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		3 interactors: APP LIG4 PXN	103 interactors: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 CAP1 CCDC176 CLU COL1A2 COMMD1 COX1 COX2 COX3 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C ND1 ND4 ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID		1716	3981
HPRD ID		03273	03500
Ensembl ID		ENSG00000114956	ENSG00000174405
Uniprot IDs		D6W5I0 E5KSL5 E5KSL6 Q16854	P49917
PDB IDs		2OCP	1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP
Enriched GO Terms of Interacting Partners?		Neuron Apoptotic Process Neuron Death DNA Ligation Involved In DNA Recombination Cell Adhesion Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Cell Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lagging Strand Elongation Pro-B Cell Differentiation Axon Choice Point Recognition Establishment Of Integrated Proviral Latency Response To Oxidative Stress Response To Radiation Neuron Remodeling Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Lymphoid Progenitor Cell Differentiation DNA Ligation Signal Complex Assembly Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Cellular Copper Ion Homeostasis Cell Activation Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Copper Ion Homeostasis Suckling Behavior Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Cell Differentiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Growth Hormone Receptor Signaling Pathway Response To Stress Regulation Of Kinase Activity Cellular Response To Growth Hormone Stimulus Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Neuron Maturation MRNA Polyadenylation Focal Adhesion Assembly Response To Lithium Ion Regulation Of Epidermal Growth Factor-activated Receptor Activity	Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization DNA Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress Metabolic Process Cell Cycle Process Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Response To Stress Regulation Of Protein Catabolic Process Cell Cycle Checkpoint Mitochondrial Electron Transport, NADH To Ubiquinone Mitotic Cell Cycle Checkpoint Positive Regulation Of Signal Transduction By P53 Class Mediator Viral Process Response To Radiation Mitotic Cell Cycle Process Protein Metabolic Process Negative Regulation Of Cell Cycle Response To Gamma Radiation Posttranscriptional Regulation Of Gene Expression Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Translation Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Mitotic Cell Cycle Electron Transport Chain Regulation Of Protein Ubiquitination Regulation Of Response To DNA Damage Stimulus Cell Cycle V(D)J Recombination Pro-B Cell Differentiation Cellular Protein Metabolic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		candidate center cholestasis clarify copy deoxyguanosine depletion failure hepatocerebral histopathologic infantile infants leukocytes liver manifested mitochondrial mpv17 muscle mutations pathogenic polymerase progressive radiologic referred representing sequenced skeletal suspected tertiary	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Difference) ?		candidate center cholestasis clarify copy deoxyguanosine depletion failure hepatocerebral histopathologic infantile infants leukocytes liver manifested mitochondrial mpv17 muscle mutations pathogenic polymerase progressive radiologic referred representing sequenced skeletal suspected tertiary	ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining
Tagcloud (Intersection) ?