ARHGAP21 and EEF1D

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		ARHGAP21	EEF1D
Gene Name		Rho GTPase activating protein 21	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytoskeleton Cell Junction Cytoplasmic Vesicle Membrane	Nucleus Nucleolus Cytoplasm Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Rho GTPase Activator Activity Protein Binding	DNA Binding Translation Elongation Factor Activity Signal Transducer Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding
	Biological Process	Golgi Organization Signal Transduction Positive Regulation Of Rho GTPase Activity Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Translation Translational Elongation Signal Transduction Gene Expression Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process
Pathways			Translation Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ARF1 EEF1D PTK2B RHOA SP1 ZNF177	33 interactors: ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS ERP27 FOS FRA10AC1 GARS HEXDC KARS KTN1 MAP1B NR2F1 POT1 PRKCA RELA RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 VARS
Entrez ID		57584	1936
HPRD ID		06445	00560
Ensembl ID		ENSG00000107863	ENSG00000104529
Uniprot IDs		Q5T5U3	B2RAR6 D3DWK1 P29692
PDB IDs		2DHJ 2J59 2YUY
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Signaling Viral Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of CGMP-mediated Signaling Negative Regulation Of Nodal Signaling Pathway Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Intracellular Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Activation Of Janus Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Positive Regulation Of Neuron Projection Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Inositol Trisphosphate Biosynthetic Process Determination Of Left/right Asymmetry In Lateral Mesoderm Apolipoprotein A-I-mediated Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Nodal Signaling Pathway Cleavage Furrow Formation Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Cell Projection Organization Cell Projection Organization Ossification Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Positive Regulation By Host Of Viral Transcription Activation Of Rac GTPase Activity Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macrophage Chemotaxis Stress Fiber Assembly Embryonic Process Involved In Female Pregnancy Positive Regulation Of Neuron Differentiation COPI-coated Vesicle Budding Glial Cell Proliferation	Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To External Stimulus Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Axonogenesis Regulation Of Telomere Maintenance Via Telomerase Axon Development Negative Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Cellular Metabolic Process Toll-like Receptor 10 Signaling Pathway Cell Differentiation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Telomere Maintenance Toll-like Receptor 3 Signaling Pathway Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Viral Genome Replication Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Schwann Cell Differentiation Neuron Projection Development Neurotrophin TRK Receptor Signaling Pathway Cell Projection Morphogenesis Nucleobase-containing Compound Metabolic Process Axon Guidance Chemotaxis Neurotrophin Signaling Pathway Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Histone H4 Acetylation
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