WRNIP1 and POLD2

Number of citations of the paper that reports this interaction (PMID 15670210)
7

Data Source:
HPRD (in vitro)

		WRNIP1	POLD2
Gene Name		Werner helicase interacting protein 1	polymerase (DNA directed), delta 2, accessory subunit
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Gene Ontology Annotations	Cellular Component	Nucleus Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding ATP Binding ATPase Activity Identical Protein Binding Metal Ion Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication Regulation Of DNA-dependent DNA Replication Initiation	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways			Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ABL1 DDX58 PIN1 POLD1 POLD2 POLD4 TOLLIP WRN	16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1
Entrez ID		56897	5425
HPRD ID		10494	15982
Ensembl ID		ENSG00000124535	ENSG00000106628
Uniprot IDs		Q96S55	A4D2J4 B2R5S4 P49005
PDB IDs		3VHS 3VHT	3E0J
Enriched GO Terms of Interacting Partners?		Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication DNA Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To Stress Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process DNA Synthesis Involved In DNA Repair Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of ERK1 And ERK2 Cascade Chromosome Organization Response To Stimulus Cell Cycle Process DNA Replication Proofreading Transitional One Stage B Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Immune Response Regulation Of Type I Interferon Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Defense Response Regulation Of Cytokine Production Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Response To UV Regulation Of Cell Motility Regulation Of Growth Rate Cellular Response To Dopamine Nucleolus To Nucleoplasm Transport RIG-I Signaling Pathway	DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process
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