WRNIP1 and POLD1

Number of citations of the paper that reports this interaction (PMID 15670210)
7

Data Source:
HPRD (in vitro)

		WRNIP1	POLD1
Gene Name		Werner helicase interacting protein 1	polymerase (DNA directed), delta 1, catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Membrane Perinuclear Region Of Cytoplasm	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Cytoplasm Membrane Aggresome Delta DNA Polymerase Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding ATPase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5'-exodeoxyribonuclease Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication Regulation Of DNA-dependent DNA Replication Initiation	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Catabolic Process, Exonucleolytic DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, Gap-filling Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Response To UV Telomere Maintenance Via Semi-conservative Replication Small Molecule Metabolic Process DNA Replication Proofreading Fatty Acid Homeostasis
Pathways			Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Cytosolic iron-sulfur cluster assembly Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ABL1 DDX58 PIN1 POLD1 POLD2 POLD4 TOLLIP WRN	16 interactors: ATR CCND3 CCNE1 CDK2 CDK4 CHGB GINS4 KIAA1377 PCNA POLD2 POLD3 POLD4 TERF2IP TREX2 WRNIP1 XRCC5
Entrez ID		56897	5424
HPRD ID		10494	08882
Ensembl ID		ENSG00000124535	ENSG00000062822
Uniprot IDs		Q96S55	M0R2B7 P28340 Q59FA0
PDB IDs		3VHS 3VHT
Enriched GO Terms of Interacting Partners?		Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication DNA Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To Stress Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process DNA Synthesis Involved In DNA Repair Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of ERK1 And ERK2 Cascade Chromosome Organization Response To Stimulus Cell Cycle Process DNA Replication Proofreading Transitional One Stage B Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Immune Response Regulation Of Type I Interferon Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Defense Response Regulation Of Cytokine Production Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Response To UV Regulation Of Cell Motility Regulation Of Growth Rate Cellular Response To Dopamine Nucleolus To Nucleoplasm Transport RIG-I Signaling Pathway	DNA Replication DNA Metabolic Process Telomere Maintenance DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening DNA Repair Cell Cycle DNA-dependent DNA Replication Mitotic Cell Cycle Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Cell Cycle Process Mitotic Recombination Cellular Response To Stress DNA Recombination DNA Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Chromosome Organization Mismatch Repair Base-excision Repair Nucleotide-excision Repair Response To Stress Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cellular Response To Stimulus Nitrogen Compound Metabolic Process Regulation Of DNA-dependent DNA Replication Initiation Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process DNA Synthesis Involved In DNA Repair Response To Stimulus Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Homeostatic Process Cell Division Cellular Response To Ionizing Radiation Positive Regulation Of Deoxyribonuclease Activity
Tagcloud ?			19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt
Tagcloud (Difference) ?			19q13 adenoma arm atp1a3 bands bckdha benign boundary breakpoint chromosome communication cosmids cytogenetic distal ercc1 establishment mapped mapping p35 p36 probes q13 ryr1 subset sv40 thyroid transformed translocations trpt
Tagcloud (Intersection) ?