PRLR and PRL

Number of citations of the paper that reports this interaction (PMID 9626554)
112

Data Source:
HPRD (in vitro, in vivo)

		PRLR	PRL
Gene Name		prolactin receptor	prolactin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen	Extracellular Region
	Molecular Function	Prolactin Receptor Activity Protein Binding Peptide Hormone Binding Protein Homodimerization Activity Ornithine Decarboxylase Activator Activity Metal Ion Binding	Prolactin Receptor Binding Hormone Activity Protein Binding
	Biological Process	Steroid Biosynthetic Process Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Prolactin Signaling Pathway T Cell Activation Activation Of JAK2 Kinase Activity Negative Regulation Of Apoptotic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development	Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Cell Proliferation Regulation Of Multicellular Organism Growth Positive Regulation Of JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Amyloids Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling
Drugs		Somatropin recombinant Fluoxymesterone
Diseases
GWAS			Paget's disease ( 21623375) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		18 interactors: CISH CREBBP CSH1 FBXW11 GH1 JAK2 NEK3 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70	3 interactors: PPIB PRLR UBQLN4
Entrez ID		5618	5617
HPRD ID		01457	07180
Ensembl ID		ENSG00000113494	ENSG00000172179
Uniprot IDs		P16471	P01236 Q5THQ0
PDB IDs		1BP3 2LFG 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF	1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Enzyme Linked Receptor Protein Signaling Pathway Response To Peptide Hormone Response To Peptide Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of JAK-STAT Cascade Response To Organonitrogen Compound Regulation Of Signal Transduction Response To Hormone Cellular Response To Organic Substance Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Communication Response To Organic Substance Regulation Of Kinase Activity Innate Immune Response Immune System Process Cellular Response To Stimulus Immune Response Regulation Of Body Fluid Levels Wound Healing Defense Response Response To Stimulus Negative Regulation Of JAK-STAT Cascade Regulation Of Cellular Response To Insulin Stimulus Response To Wounding Blood Coagulation Hemostasis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Immune Response Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Protein Modification Process	Activation Of JAK2 Kinase Activity Prolactin Signaling Pathway Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Activation Of Janus Kinase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prostate Gland Growth Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Viral Genome Replication JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Interaction With Symbiont Peptidyl-amino Acid Modification Response To Growth Hormone Mammary Gland Alveolus Development Mammary Gland Lobule Development
Tagcloud ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum prolactin reporter responsive sh2 slightly stat5 tagged transfected transiently	adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prolactin pronounced putative rodents stat1 stat5 take ways
Tagcloud (Difference) ?		abolished cdna cdnas changed cis1 cis2 cis3 cis4 comparable expressions gland glands hint inducible jab little luciferase mammary myc postpartum reporter responsive sh2 slightly tagged transfected transiently	adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy pronounced putative rodents stat1 take ways
Tagcloud (Intersection) ?		prolactin stat5