PRL and PPIB

Number of citations of the paper that reports this interaction (PMID 10935542)
19

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PRL	PPIB
Gene Name		prolactin	peptidylprolyl isomerase B (cyclophilin B)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Macromolecular Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Prolactin Receptor Binding Hormone Activity Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Collagen Binding Protein Complex Binding Peptide Binding Poly(A) RNA Binding Unfolded Protein Binding RNA Polymerase Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Female Pregnancy Lactation Cell Proliferation Regulation Of Multicellular Organism Growth Positive Regulation Of JAK-STAT Cascade JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Protein Peptidyl-prolyl Isomerization Extracellular Matrix Organization Positive Regulation Of Multicellular Organism Growth Positive Regulation By Host Of Viral Process Positive Regulation By Host Of Viral Genome Replication Protein Stabilization Bone Development Chaperone-mediated Protein Folding Regulation Of Post-translational Protein Modification
Pathways		Amyloids Nuclear signaling by ERBB4 Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Collagen formation Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Paget's disease ( 21623375) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		3 interactors: PPIB PRLR UBQLN4	15 interactors: APOB ATP12A BANP CAMLG DNM2 HIST3H3 IRF3 MDM2 PEX19 PRL SGTA STAT5A UBQLN1 UBQLN4 VKORC1
Entrez ID		5617	5479
HPRD ID		07180	00458
Ensembl ID		ENSG00000172179	ENSG00000166794
Uniprot IDs		P01236 Q5THQ0	P23284
PDB IDs		1RW5 2Q98 3D48 3EW3 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 3NPZ	1CYN 3ICH 3ICI
Enriched GO Terms of Interacting Partners?		Activation Of JAK2 Kinase Activity Prolactin Signaling Pathway Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Activation Of Janus Kinase Activity Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Prostate Gland Growth Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Viral Genome Replication JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Interaction With Symbiont Peptidyl-amino Acid Modification Response To Growth Hormone Mammary Gland Alveolus Development Mammary Gland Lobule Development	Positive Regulation Of Mitotic Cell Cycle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Viral Process Regulation Of Body Fluid Levels Cellular Response To Hormone Stimulus JAK-STAT Cascade Positive Regulation Of Mitotic Cell Cycle Phase Transition Lactation Positive Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Lipid Binding Negative Regulation Of Interferon-beta Biosynthetic Process Cellular Response To UV-C Positive Regulation Of Mast Cell Differentiation Cellular Response To Vitamin B1 Regulation Of Developmental Growth Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Receptor Metabolic Process Immune System Process Negative Regulation Of Membrane Tubulation MDA-5 Signaling Pathway Macrophage Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Steroid Metabolic Process Regulation Of Multicellular Organism Growth Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Mast Cell Differentiation Development Of Secondary Male Sexual Characteristics Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Biosynthetic Process Body Fluid Secretion Cellular Response To Lipid Cellular Response To Oxygen Levels Response To Hormone Traversing Start Control Point Of Mitotic Cell Cycle Peroxisome Membrane Biogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Negative Regulation Of Mast Cell Apoptotic Process Response To Vitamin B1 Response To Ether Negative Regulation Of Defense Response To Virus By Host
Tagcloud ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prolactin pronounced putative rodents stat1 stat5 take ways	abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation
Tagcloud (Difference) ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prolactin pronounced putative rodents stat1 stat5 take ways	abeta abundance accompanies ad animal biomarkers cytokines diverse elisa immunostaining isotope key labeling lack lc microglia microglial ms nervous neurodegenerative neuroinflammation pdia3 pdia6 proper proteomic resident serpinh1 silac validation
Tagcloud (Intersection) ?