MAPK4 and GAB1

Number of citations of the paper that reports this interaction (PMID 12008033)
12

Data Source:
HPRD (in vitro)

		MAPK4	GAB1
Gene Name		mitogen-activated protein kinase 4	GRB2-associated binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol
	Molecular Function	MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle	Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Activation Of JUN Kinase Activity Heart Development Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Labyrinthine Layer Development Interleukin-6-mediated Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling IRS-related events triggered by IGF1R PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR PI3K Cascade Innate Immune System Signaling by Insulin receptor Signaling by PDGF Signalling by NGF DAP12 interactions Insulin receptor signalling cascade GAB1 signalosome IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR IRS-mediated signalling Downstream signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII PI3K Cascade Adaptive Immune System
Drugs
Diseases
GWAS			Asthma ( 21804548)
Protein-Protein Interactions		7 interactors: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5 UBC	31 interactors: ARHGAP32 C1QBP CRK CRKL EGFR EPOR FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1
Entrez ID		5596	2549
HPRD ID		01497	05116
Ensembl ID		ENSG00000141639	ENSG00000109458
Uniprot IDs		A1A4C4 P31152 Q0VG04	Q13480 Q9HA84
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activation Of MAPK Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Immune System Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Immune Response Signal Transduction Regulation Of Immune System Process Defense Response Signaling JNK Cascade Regulation Of Signaling Cell Communication Cellular Response To Growth Factor Stimulus	Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Immune Response Positive Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Immune Response Activation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation ERBB Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Defense Response Wound Healing Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Response To Fibroblast Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Response To Wounding Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Protein Modification Process
Tagcloud ?			adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Difference) ?			adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride
Tagcloud (Intersection) ?