GAB1 and MST1R

Number of citations of the paper that reports this interaction (PMID 14982882)
14

Data Source:
HPRD (two hybrid)

		GAB1	MST1R
Gene Name		GRB2-associated binding protein 1	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Stress Fiber Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding	Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Response To Oxidative Stress Epidermal Growth Factor Receptor Signaling Pathway Activation Of JUN Kinase Activity Heart Development Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Labyrinthine Layer Development Interleukin-6-mediated Signaling Pathway	Movement Of Cell Or Subcellular Component Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Single Fertilization Positive Regulation Of Cell Proliferation Response To Virus Peptidyl-tyrosine Phosphorylation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase B Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling IRS-mediated signalling IGF1R signaling cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling IRS-related events triggered by IGF1R PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR PI3K Cascade Innate Immune System Signaling by Insulin receptor Signaling by PDGF Signalling by NGF DAP12 interactions Insulin receptor signalling cascade GAB1 signalosome IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR IRS-mediated signalling Downstream signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Signaling by FGFR mutants PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII PI3K Cascade Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 21804548)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		31 interactors: ARHGAP32 C1QBP CRK CRKL EGFR EPOR FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1	21 interactors: AKT1 EPOR GAB1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2549	4486
HPRD ID		05116	02545
Ensembl ID		ENSG00000109458	ENSG00000164078
Uniprot IDs		Q13480 Q9HA84	B4E058 Q04912
PDB IDs			3PLS 4FWW
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Immune Response Positive Regulation Of MAPK Cascade Enzyme Linked Receptor Protein Signaling Pathway Immune Response Activation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation ERBB Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Defense Response Wound Healing Signaling Cellular Response To Fibroblast Growth Factor Stimulus Cell Communication Response To Fibroblast Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of MAP Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity Response To Wounding Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Protein Modification Process	Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Signaling Fc Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organic Substance Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Mitochondrion Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Mitochondrion Organization Signal Transduction Response To Peptide Hormone Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Organonitrogen Compound Cellular Response To Stimulus Response To Peptide Response To Organic Substance Signaling Apoptotic Signaling Pathway Defense Response Multicellular Organismal Development Cell Communication
Tagcloud ?		adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Difference) ?		adaptor amplifies antagonism bdl bile binder broad ccl5 chemokine conditional contributor duct elucidate exacerbated fibrogenesis fibrosis fibrotic gab1cko grb2 hepatocyte hepatocytes injections knockout ligation lipopolysaccharide liver livers myofibroblasts tetrachloride	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Intersection) ?