PRKCQ and CISH

Number of citations of the paper that reports this interaction (PMID 12618484)
4

Data Source:
HPRD (in vitro)

		PRKCQ	CISH
Gene Name		protein kinase C, theta	cytokine inducible SH2-containing protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane	Cellular_component Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Metal Ion Binding	Molecular_function Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Inflammatory Response Axon Guidance Blood Coagulation Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Protein Ubiquitination Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation	Regulation Of Cell Growth Negative Regulation Of Protein Kinase Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Pathways		G alpha (q) signalling events Signaling by GPCR Downstream TCR signaling Axon guidance Effects of PIP2 hydrolysis FCERI mediated NF-kB activation Inactivation, recovery and regulation of the phototransduction cascade Gastrin-CREB signalling pathway via PKC and MAPK The phototransduction cascade Programmed Cell Death G alpha (z) signalling events Netrin-1 signaling Innate Immune System Apoptotic cleavage of cellular proteins Apoptotic execution phase Diseases associated with visual transduction G alpha (q) signalling events GPCR downstream signaling TCR signaling Visual phototransduction Fc epsilon receptor (FCERI) signaling Platelet activation, signaling and aggregation Adaptive Immune System	Cytokine Signaling in Immune system Growth hormone receptor signaling
Drugs		Staurosporine Phosphonothreonine Phosphonoserine
Diseases
GWAS		Asthma (bronchodilator response) ( 23508266) Body mass index (asthmatics) ( 23517042) Immune response to smallpox vaccine (IL-6) ( 22542470) Rheumatoid arthritis ( 18794853 20453842) Type 1 diabetes ( 19430480 18978792)
Protein-Protein Interactions		28 interactors: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN NFE2L2 RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ	18 interactors: CSF2RB CSF3R EGFR EPOR ERBB2 ETV5 GHR HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2
Entrez ID		5588	1154
HPRD ID		02710	03897
Ensembl ID		ENSG00000065675	ENSG00000114737
Uniprot IDs		Q04759	Q9NSE2
PDB IDs		1XJD 2ENJ 2ENN 2ENZ 2JED
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Immune System Process T Cell Costimulation Regulation Of Cell Death Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor T Cell Receptor Signaling Pathway Signal Transduction Regulation Of Signaling Immune Response Regulation Of Lymphocyte Activation Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Defense Response Lymphocyte Homeostasis Signaling Response To Growth Factor Cell Communication Response To Organic Substance Response To Stress Cellular Response To Stimulus Regulation Of T Cell Activation Leukocyte Homeostasis Phosphorylation Positive Regulation Of Cell Activation Regulation Of Cell Activation Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	Cellular Response To Organic Substance Response To Organic Substance Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Cytokine Stimulus Cellular Response To Stimulus Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Protein Phosphorylation Phosphorylation Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Histone H3-T6 Phosphorylation Erythropoietin-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Peptidyl-tyrosine Phosphorylation Activation Of JAK2 Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Metabolic Process Peptidyl-amino Acid Modification Response To Growth Factor Chemotaxis Negative Regulation Of Cell Death Cellular Response To Erythropoietin Regulation Of MAPK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Response To Interleukin-3 Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3d cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 rpa3 softwares vav3 zap70	adenocarcinomas applicable appropriately chromogenic clinicopathologic differentiating diffuse disagreement educated esophageal gastroesophageal her2 histologically ihc interobserver introduced junction oncogene pathologists positivity retrieved retrospectively scoring stained standardized trained validate variability
Tagcloud (Intersection) ?