PRKAB1 and PRKAG1

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
HPRD (two hybrid)

		PRKAB1	PRKAG1
Gene Name		protein kinase, AMP-activated, beta 1 non-catalytic subunit	protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol AMP-activated Protein Kinase Complex	Nucleus Cytosol Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Binding ADP Binding
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Spermatogenesis Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs		Adenosine monophosphate Metformin
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3	15 interactors: ACACA AP1S3 C1orf94 CBS KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1
Entrez ID		5564	5571
HPRD ID		04116	04118
Ensembl ID		ENSG00000111725	ENSG00000181929
Uniprot IDs		Q9Y478	F8W9D1 P54619
PDB IDs			2UV4 2UV5 2UV6 2UV7
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Energy Reserve Metabolic Process Cellular Response To Peptide Hormone Stimulus Carnitine Shuttle Fatty Acid Metabolic Process Cellular Response To Peptide Cell Cycle Arrest Carnitine Transmembrane Transport Carnitine Transport Generation Of Precursor Metabolites And Energy Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Phosphorylation Response To Peptide Quaternary Ammonium Group Transport Phosphate-containing Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Small Molecule Metabolic Process Sterol Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Carbohydrate Metabolic Process Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Sterol Biosynthetic Process Lipid Metabolic Process Response To Organonitrogen Compound Negative Regulation Of Cell Cycle Glycogen Metabolic Process Fatty Acid Transport Regulation Of Cell Cycle Oxidation-reduction Process Cellular Lipid Metabolic Process Cellular Protein Modification Process Ammonium Transport Steroid Metabolic Process Carboxylic Acid Metabolic Process Polysaccharide Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process	Carnitine Shuttle Carnitine Transmembrane Transport Carnitine Transport Fatty Acid Biosynthetic Process Quaternary Ammonium Group Transport Long-chain Fatty Acid Transport Fatty Acid Metabolic Process Ammonium Transmembrane Transport Cell Cycle Arrest Insulin Receptor Signaling Pathway Fatty Acid Transport Ammonium Transport Cellular Response To Insulin Stimulus Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Response To Insulin Lipid Transport Cellular Response To Peptide Hormone Stimulus Organic Acid Metabolic Process Regulation Of Glycolytic Process Lipid Localization Cellular Response To Peptide Monocarboxylic Acid Transport Regulation Of Lipid Biosynthetic Process Energy Reserve Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Mitochondrial Transport Membrane Organization Organic Anion Transport Sterol Biosynthetic Process Negative Regulation Of Cell Cycle Response To Peptide Hormone Small Molecule Metabolic Process Cellular Response To Organonitrogen Compound Response To Peptide Cellular Lipid Metabolic Process Cellular Response To Hormone Stimulus Inorganic Anion Transport Regulation Of Generation Of Precursor Metabolites And Energy Monovalent Inorganic Cation Transport Anion Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Organic Acid Transport Lipid Metabolic Process Regulation Of Energy Homeostasis
Tagcloud ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Difference) ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins
Tagcloud (Intersection) ?