PRKAB1 and PRKAG2

Number of citations of the paper that reports this interaction (PMID 10698692)
99

Data Source:
HPRD (two hybrid)

		PRKAB1	PRKAG2
Gene Name		protein kinase, AMP-activated, beta 1 non-catalytic subunit	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol AMP-activated Protein Kinase Complex	Extracellular Space Nucleoplasm Cytosol AMP-activated Protein Kinase Complex
	Molecular Function	Protein Kinase Activity AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Inhibitor Activity ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Binding Protein Kinase Activator Activity ADP Binding
	Biological Process	Protein Phosphorylation Fatty Acid Biosynthetic Process Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Protein Kinase Activity Protein Heterooligomerization Membrane Organization	Glycogen Metabolic Process Regulation Of Glycolytic Process Energy Reserve Metabolic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Organelle Organization Mitochondrion Organization Cell Cycle Arrest Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Intracellular Signal Transduction Regulation Of Fatty Acid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Membrane Organization Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Organelle biogenesis and maintenance Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling Translocation of GLUT4 to the plasma membrane IRS-related events mTOR signalling IGF1R signaling cascade Mitochondrial biogenesis IRS-related events triggered by IGF1R Activation of PPARGC1A (PGC-1alpha) by phosphorylation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor	Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs		Adenosine monophosphate Metformin
Diseases
GWAS			Bipolar disorder (age of onset and psychomotor symptoms) ( 21305692) Chronic kidney disease ( 20383146) Hematocrit ( 19862010) Hemoglobin ( 19862010) Red blood cell traits ( 23222517) Urate levels ( 23263486)
Protein-Protein Interactions		13 interactors: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3	3 interactors: PRKAB1 PRKAB2 PRKAG1
Entrez ID		5564	51422
HPRD ID		04116	04119
Ensembl ID		ENSG00000111725	ENSG00000106617
Uniprot IDs		Q9Y478	G8JLM0 Q9UGJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Fatty Acid Biosynthetic Process Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Energy Reserve Metabolic Process Cellular Response To Peptide Hormone Stimulus Carnitine Shuttle Fatty Acid Metabolic Process Cellular Response To Peptide Cell Cycle Arrest Carnitine Transmembrane Transport Carnitine Transport Generation Of Precursor Metabolites And Energy Phosphorylation Regulation Of Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Protein Phosphorylation Response To Peptide Quaternary Ammonium Group Transport Phosphate-containing Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Small Molecule Metabolic Process Sterol Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Carbohydrate Metabolic Process Long-chain Fatty Acid Transport Ammonium Transmembrane Transport Sterol Biosynthetic Process Lipid Metabolic Process Response To Organonitrogen Compound Negative Regulation Of Cell Cycle Glycogen Metabolic Process Fatty Acid Transport Regulation Of Cell Cycle Oxidation-reduction Process Cellular Lipid Metabolic Process Cellular Protein Modification Process Ammonium Transport Steroid Metabolic Process Carboxylic Acid Metabolic Process Polysaccharide Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process	Fatty Acid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Cellular Response To Peptide Hormone Stimulus Fatty Acid Metabolic Process Cellular Response To Peptide Mitochondrion Organization Negative Regulation Of Cell Cycle Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Response To Organonitrogen Compound Membrane Organization Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Response To Hormone Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cell Cycle Process Protein Heterooligomerization Regulation Of Protein Phosphorylation Organic Acid Metabolic Process Lipid Metabolic Process Regulation Of Phosphorylation Protein Phosphorylation Cell Cycle Regulation Of Phosphorus Metabolic Process Phosphorylation Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Carnitine Shuttle Regulation Of Catalytic Activity Response To Organic Substance Carnitine Transmembrane Transport Carnitine Transport Phosphate-containing Compound Metabolic Process Quaternary Ammonium Group Transport Cell Surface Receptor Signaling Pathway Organelle Organization
Tagcloud ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?		adipor1 alter amp bdkrb2 changed differential discordant epigenome exercise fh hoxc6 mapk1 mef2a methylation modifies monozygotic muscle myo18b ndufc2 pairs predispose retinol runx1 skeletal t2d thada trib1 twin twins	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency inhbc loci maaori maf meeting obvious opposing pacific pdzk1 polynesian replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Intersection) ?