PRELP and FN1

Number of citations of the paper that reports this interaction (PMID 11847210)
16

Data Source:
HPRD (in vitro)

		PRELP	FN1
Gene Name		proline/arginine-rich end leucine-rich repeat protein	fibronectin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Vesicle Lysosomal Lumen Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Basal Lamina Extracellular Space Endoplasmic Reticulum-Golgi Intermediate Compartment Apical Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding	Protease Binding Integrin Binding Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Aging Pathogenesis Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Angiogenesis Platelet Degranulation Acute-phase Response Cell-substrate Junction Assembly Cell Adhesion Calcium-independent Cell-matrix Adhesion Blood Coagulation Regulation Of Cell Shape Response To Wounding Positive Regulation Of Peptidase Activity Peptide Cross-linking Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Integrin Activation Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Positive Regulation Of Axon Extension Leukocyte Migration
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome	Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Non-integrin membrane-ECM interactions Platelet degranulation Platelet Aggregation (Plug Formation) Degradation of the extracellular matrix Cell surface interactions at the vascular wall Molecules associated with elastic fibres Syndecan interactions ECM proteoglycans Fibronectin matrix formation Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Ocriplasmin
Diseases
GWAS
Protein-Protein Interactions		7 interactors: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1 NID2	96 interactors: ADAMTS4 AMBP APCS ATXN10 ATXN7 C1QA CD44 CDKN2A COL13A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL6A2 COL7A1 COMP CRP CTSD CXCL12 DCN DUSP10 EGFR F13A1 FAM86B3P FASLG FBLN1 FBLN2 FST FSTL3 GALNT6 GRB2 GSN HGF HRG HSPG2 IGFBP3 IGFBP5 ITGA3 ITGA4 ITGA5 ITGA8 ITGB1 ITGB3 ITGB6 ITGB7 KLK3 KPNA2 LACRT LGALS3BP LPA LRG1 LTBP1 MAG MATN2 MEP1A MEP1B MIA MMP9 MYOC NOV NR0B2 NT5E PELI2 PKD1 PLAT PLG PRELP PRPF40A RARA RBL1 REG3A RPS6KA5 SCGB1A1 SDC2 SKIL SMAD4 SMAD9 SPARC STAT5A TAB1 TAB2 TAC1 TGFBI TGM2 THBS1 TMPRSS6 TNC TNFRSF11B TSHR UBQLN1 VHL
Entrez ID		5549	2335
HPRD ID		03556	00626
Ensembl ID		ENSG00000188783	ENSG00000115414
Uniprot IDs		P51888	P02751 Q6MZF4 Q6MZM7 Q6N084 Q9UQS6
PDB IDs			1E88 1E8B 1FBR 1FNA 1FNF 1FNH 1J8K 1O9A 1OWW 1Q38 1QGB 1QO6 1TTF 1TTG 2CG6 2CG7 2CK2 2CKU 2EC3 2FN2 2FNB 2GEE 2H41 2H45 2HA1 2OCF 2RKY 2RKZ 2RL0 3CAL 3EJH 3GXE 3M7P 3MQL 3R8Q 3T1W 3ZRZ 4GH7 4JE4 4JEG
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Endochondral Bone Morphogenesis Bone Morphogenesis Embryonic Skeletal System Development Cell-matrix Adhesion Basement Membrane Organization Regulation Of Cell-substrate Adhesion Cartilage Development Cell-substrate Adhesion Bone Development Connective Tissue Development Skeletal System Morphogenesis Ossification Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Collagen Fibril Organization Collagen Catabolic Process Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Multicellular Organismal Metabolic Process Cellular Response To Fluoride Blood Vessel Development Vasculature Development Proteoglycan Metabolic Process Skeletal System Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Tooth Eruption Response To Fluoride Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Tissue Development Sensory Perception Of Sound Positive Regulation Of Cell Morphogenesis Involved In Differentiation Visual Perception Calcium-independent Cell-matrix Adhesion Chordate Embryonic Development Sensory Perception Of Light Stimulus Embryo Development Ending In Birth Or Egg Hatching Sensory Perception Of Mechanical Stimulus Platelet Activation Cellular Response To Vitamin E Leukocyte Migration Organ Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Developmental Process Multicellular Organismal Development Anatomical Structure Morphogenesis System Development Anatomical Structure Development Collagen Catabolic Process Response To Stimulus Response To External Stimulus Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Cell Differentiation Wound Healing Tissue Development Response To Wounding Axon Guidance Response To Growth Factor Response To Organic Substance Organ Development Response To Stress Cellular Response To Stimulus Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neurogenesis Generation Of Neurons Chemotaxis Regulation Of Cell Adhesion Cell Adhesion Axon Development Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Axonogenesis Cell Projection Organization Cell Morphogenesis Cardiovascular System Development Nervous System Development Neuron Projection Development Skeletal System Development Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Formation Involved In Morphogenesis Neuron Development Regulation Of Locomotion Organ Morphogenesis Cell Communication Neuron Projection Morphogenesis
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	2q33 2q34 artificial bcg brazilian exon il8 il8r il8ra il8rb ity leishmaniasis leprosy linkage lod lsh nramp pedigrees proline pseudogene q35 q37 segregating sh3 synteny tnp1 typed vil1 visceral
Tagcloud (Intersection) ?