PRELP

Gene Name		proline/arginine-rich end leucine-rich repeat protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Vesicle Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Heparin Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Cell Aging Pathogenesis Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1 NID2
Entrez ID		5549
HPRD ID		03556
Ensembl ID		ENSG00000188783
Uniprot IDs		P51888
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Endochondral Bone Morphogenesis Bone Morphogenesis Embryonic Skeletal System Development Cell-matrix Adhesion Basement Membrane Organization Regulation Of Cell-substrate Adhesion Cartilage Development Cell-substrate Adhesion Bone Development Connective Tissue Development Skeletal System Morphogenesis Ossification Cardiovascular System Development Anatomical Structure Formation Involved In Morphogenesis Collagen Fibril Organization Collagen Catabolic Process Embryo Development Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Multicellular Organismal Metabolic Process Cellular Response To Fluoride Blood Vessel Development Vasculature Development Proteoglycan Metabolic Process Skeletal System Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Tooth Eruption Response To Fluoride Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Tissue Development Sensory Perception Of Sound Positive Regulation Of Cell Morphogenesis Involved In Differentiation Visual Perception Calcium-independent Cell-matrix Adhesion Chordate Embryonic Development Sensory Perception Of Light Stimulus Embryo Development Ending In Birth Or Egg Hatching Sensory Perception Of Mechanical Stimulus Platelet Activation Cellular Response To Vitamin E Leukocyte Migration Organ Morphogenesis
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal lgals1 pancreas pancreatic pdac personalized prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts