ARHGAP17 and PACSIN1

Number of citations of the paper that reports this interaction (PMID 11431473)
23

Data Source:
HPRD (in vitro)

		ARHGAP17	PACSIN1
Gene Name		Rho GTPase activating protein 17	protein kinase C and casein kinase substrate in neurons 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Tight Junction	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10	24 interactors: ANKRD24 ARHGAP17 ATP8 COBL COBLL1 DNM1 EHBP1 FTH1 GAS7 HTT JADE2 KAT7 KHDRBS1 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		55114	29993
HPRD ID		12207	05936
Ensembl ID		ENSG00000140750	ENSG00000124507
Uniprot IDs		Q68EM7	Q5TZC3 Q9BY11
PDB IDs			3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?		Endocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway T Cell Costimulation Innate Immune Response Platelet Activation Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Phagocytosis Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune Response Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Cell-cell Adhesion Neuron Projection Morphogenesis Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Activation Neuron Projection Development Cell Migration Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of T Cell Activation Cell Projection Morphogenesis Locomotion Transport Regulation Of Signaling	Cell Projection Morphogenesis Cell Part Morphogenesis Actin Filament-based Process Endocytosis Cellular Component Assembly Vesicle-mediated Transport Cell Morphogenesis Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Organization Cell Projection Organization Actin Cytoskeleton Organization Neuron Development Neuron Projection Morphogenesis Regulation Of Endocytosis Actin Filament-based Movement Endomembrane System Organization Generation Of Neurons Neuron Differentiation Histone H4-K12 Acetylation Membrane Tubulation Neurogenesis Neuron Projection Development Actin Polymerization Or Depolymerization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Axonogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Protein Polymerization Anatomical Structure Morphogenesis Axon Development Regulation Of Cellular Process Regulation Of Protein Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Organization Cell Morphogenesis Involved In Neuron Differentiation Membrane Assembly Regulation Of Cell Projection Assembly Regulation Of Protein Complex Disassembly Protein Complex Assembly Movement Of Cell Or Subcellular Component Cellular Protein Complex Assembly Membrane Biogenesis Cell Differentiation Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Complex Disassembly Cell Morphogenesis Involved In Differentiation Axon Guidance
Tagcloud ?			10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Difference) ?			10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Intersection) ?