PLEKHB2 and EPN1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLEKHB2	EPN1
Gene Name		pleckstrin homology domain containing, family B (evectins) member 2	epsin 1
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Gene Ontology Annotations	Cellular Component	Recycling Endosome Membrane	Nucleus Cytoplasm Plasma Membrane Coated Pit
	Molecular Function		Transcription Factor Binding Lipid Binding
	Biological Process		In Utero Embryonic Development Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Female Pregnancy Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640)
Protein-Protein Interactions		8 interactors: ATF7IP BHLHE40 C1orf94 CDA DAZAP2 EPN1 STAM2 UPF1	20 interactors: AP2A1 AP2A2 CDK1 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 KIAA1377 LAPTM5 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G UBC ZBTB16
Entrez ID		55041	29924
HPRD ID		15144	06270
Ensembl ID		ENSG00000115762	ENSG00000063245
Uniprot IDs		Q96CS7	Q9Y6I3
PDB IDs		3AJ4 3VIA	1INZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Gene Expression, Epigenetic Cytosine Metabolic Process Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Cytidine Deamination Histone MRNA Catabolic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Dosage Compensation Pyrimidine Nucleoside Catabolic Process Aromatic Compound Catabolic Process Histone MRNA Metabolic Process Entrainment Of Circadian Clock By Photoperiod Regulation Of DNA-templated Transcription, Initiation Photoperiodism Entrainment Of Circadian Clock Regulation Of Cellular Component Organization Pyrimidine Nucleobase Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Sodium Ion Homeostasis Negative Regulation Of Hyaluronan Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Excretion Multicellular Organismal Water Homeostasis Water Homeostasis Sensory Perception Of Taste Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Golgi To Endosome Transport Endocytosis Regulation Of Defense Response To Virus By Virus Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Clathrin-mediated Endocytosis Sodium Ion Transmembrane Transport Endosomal Transport Axonogenesis Axon Development Toll-like Receptor 5 Signaling Pathway Protein Ubiquitination Toll-like Receptor 10 Signaling Pathway Cellular Response To Growth Factor Stimulus Pronuclear Fusion Sodium Ion Transport Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Chemotaxis Response To Growth Factor Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Protein Modification By Small Protein Conjugation Golgi Vesicle Transport Toll-like Receptor 9 Signaling Pathway
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