EPN1 and SCNN1A

Number of citations of the paper that reports this interaction (PMID 16574660)
30

Data Source:
BioGRID (pull down)

		EPN1	SCNN1A
Gene Name		epsin 1	sodium channel, non voltage gated 1 alpha subunit
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Coated Pit	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Factor Binding Lipid Binding	Actin Binding Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	In Utero Embryonic Development Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Female Pregnancy Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Embryonic Organ Development	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport
Pathways		Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Ion channel transport Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases
GWAS		Major depressive disorder ( 23377640)	Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		20 interactors: AP2A1 AP2A2 CDK1 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 KIAA1377 LAPTM5 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G UBC ZBTB16	16 interactors: CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		29924	6337
HPRD ID		06270	02575
Ensembl ID		ENSG00000063245	ENSG00000111319
Uniprot IDs		Q9Y6I3	F5GXE6 P37088
PDB IDs		1INZ	2M3O
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Sodium Ion Homeostasis Negative Regulation Of Hyaluronan Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Excretion Multicellular Organismal Water Homeostasis Water Homeostasis Sensory Perception Of Taste Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Golgi To Endosome Transport Endocytosis Regulation Of Defense Response To Virus By Virus Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Clathrin-mediated Endocytosis Sodium Ion Transmembrane Transport Endosomal Transport Axonogenesis Axon Development Toll-like Receptor 5 Signaling Pathway Protein Ubiquitination Toll-like Receptor 10 Signaling Pathway Cellular Response To Growth Factor Stimulus Pronuclear Fusion Sodium Ion Transport Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Chemotaxis Response To Growth Factor Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Protein Modification By Small Protein Conjugation Golgi Vesicle Transport Toll-like Receptor 9 Signaling Pathway	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Viral Life Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Sodium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Interaction With Host Cellular Protein Modification Process Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Excretion Protein Polyubiquitination Regulation Of Signaling Regulation Of Potassium Ion Transport Water Homeostasis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Membrane Potential Regulation Of Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transport Regulation Of Transmembrane Transporter Activity Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?			aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Difference) ?			aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Intersection) ?