PPBP and PMAIP1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PPBP	PMAIP1
Gene Name		pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	phorbol-12-myristate-13-acetate-induced protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Glucose Transmembrane Transporter Activity Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding	Protein Binding
	Biological Process	Leukocyte Migration Involved In Inflammatory Response Platelet Degranulation Positive Regulation Of Leukocyte Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Blood Coagulation Glucose Transport Platelet Activation Response To Lipopolysaccharide Regulation Of Cell Proliferation Defense Response To Bacterium Positive Regulation Of Cell Division Cell Chemotaxis Chemokine-mediated Signaling Pathway	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To UV Response To X-ray Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Oligomerization Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Fibroblast Proliferation Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Platelet degranulation GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Response to elevated platelet cytosolic Ca2+ G alpha (i) signalling events Platelet activation, signaling and aggregation	Activation of NOXA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs		Ethanesulfonic Acid
Diseases
GWAS		Metabolite levels ( 22916037)	Body mass index ( 23669352) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		21 interactors: CELF1 CMTM6 COPG1 COPS7A COX17 CSNK2A1 CTSG CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4	9 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 GSK3B MCL1 PPBP ZBTB16
Entrez ID		5473	5366
HPRD ID		07171	12002
Ensembl ID			ENSG00000141682
Uniprot IDs		P02775	Q13794 Q8N589
PDB IDs		1F9P 1NAP 1TVX	3MQP
Enriched GO Terms of Interacting Partners?		Interleukin-8-mediated Signaling Pathway Chemotaxis Response To External Stimulus Dendritic Cell Chemotaxis Dendritic Cell Migration Locomotion Cell Chemotaxis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Receptor Internalization Movement Of Cell Or Subcellular Component Vesicle Docking Involved In Exocytosis Negative Regulation Of Neutrophil Apoptotic Process Basolateral Protein Localization Chemokine-mediated Signaling Pathway Golgi Vesicle Transport Vesicle Docking Neutrophil Mediated Killing Of Gram-positive Bacterium Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Membrane Docking Post-Golgi Vesicle-mediated Transport Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Autophagic Vacuole Assembly Establishment Of Neuroblast Polarity Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Defense Response Leukocyte Chemotaxis Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Endopeptidase Activity Cell Migration Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Membrane Organization Regulation Of Peptidase Activity Vesicle-mediated Transport Immune System Process Negative Regulation Of Mitochondrial Membrane Potential Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Cell Motility Regulation Of Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Intracellular Transport Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Dendritic Spine Development Mitral Valve Morphogenesis Mitral Valve Development	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Cell Death Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Negative Regulation Of Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Death Apoptotic Mitochondrial Changes Negative Regulation Of Signal Transduction Negative Regulation Of Anoikis Positive Regulation Of Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Signaling Regulation Of Mitochondrion Organization Regulation Of Anoikis Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress Cellular Response To DNA Damage Stimulus Male Gonad Development Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Nitrogen Utilization Regulation Of Intracellular Signal Transduction Male Sex Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Sertoli Cell Proliferation Response To Gamma Radiation Cell Surface Receptor Signaling Pathway Neuron Apoptotic Process Gonad Development Development Of Primary Sexual Characteristics
Tagcloud ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		10q 4q another chemokine constitutes cr cxc divergent evolutionary gcp2 genbridge gro1 gro2 gro3 il8 inp10 mapped mentioned mig pair panel pf4 pf4v1 phylogenetic physically primers scyb5 sdf1 separated	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?