PMAIP1 and ZBTB16

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PMAIP1	ZBTB16
Gene Name		phorbol-12-myristate-13-acetate-induced protein 1	zinc finger and BTB domain containing 16
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Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Cytosol	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex
	Molecular Function	Protein Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To UV Response To X-ray Proteasomal Protein Catabolic Process Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Oligomerization Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To DsRNA Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Fibroblast Proliferation Defense Response To Virus Cellular Response To Hypoxia Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Reactive Oxygen Species Metabolic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Activation of NOXA and translocation to mitochondria Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Body mass index ( 23669352) Metabolic syndrome ( 20694148)	Conduct disorder (interaction) ( 18846501)
Protein-Protein Interactions		9 interactors: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 GSK3B MCL1 PPBP ZBTB16	111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		5366	7704
HPRD ID		12002	11762
Ensembl ID		ENSG00000141682	ENSG00000109906
Uniprot IDs		Q13794 Q8N589	Q05516
PDB IDs		3MQP	1BUO 1CS3
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway Cell Death Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Negative Regulation Of Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Death Apoptotic Mitochondrial Changes Negative Regulation Of Signal Transduction Negative Regulation Of Anoikis Positive Regulation Of Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Signaling Regulation Of Mitochondrion Organization Regulation Of Anoikis Release Of Cytochrome C From Mitochondria Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Stress Cellular Response To DNA Damage Stimulus Male Gonad Development Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Nitrogen Utilization Regulation Of Intracellular Signal Transduction Male Sex Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Sertoli Cell Proliferation Response To Gamma Radiation Cell Surface Receptor Signaling Pathway Neuron Apoptotic Process Gonad Development Development Of Primary Sexual Characteristics	Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process
Tagcloud ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly sqstm1 sy5y trp53 unmask	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Difference) ?		akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly sqstm1 sy5y trp53 unmask	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Intersection) ?