MED1 and SREBF1

Number of citations of the paper that reports this interaction (PMID 16799563)
79

Data Source:
BioGRID (pull down)

		MED1	SREBF1
Gene Name		mediator complex subunit 1	sterol regulatory element binding transcription factor 1
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Cofactor Activity Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Mediator Complex Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding LBD Domain Binding	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Protein Complex Binding Sterol Response Element Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Androgen Biosynthetic Process Brain Development Lactation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Enucleate Erythrocyte Development Regulation Of Cell Cycle Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition ERK1 And ERK2 Cascade Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Receptor Activity Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Rate By Chemical Signal Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Lipid Metabolic Process Aging Circadian Rhythm Cholesterol Metabolic Process Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Cellular Response To Starvation Response To Glucose Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Lung Development Positive Regulation Of Histone Deacetylation Response To Food Response To Retinoic Acid Response To Progesterone Response To Glucagon Response To Drug Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Insulin Secretion Response To CAMP Cellular Response To Fatty Acid
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	RORA activates circadian gene expression
Drugs
Diseases
GWAS			Parkinson's disease ( 21738487)
Protein-Protein Interactions		42 interactors: AR BRCA1 CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MDM2 MED12 MED14 MED25 MED29 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RORA RXRA RXRB SREBF1 THRA THRB TP53 VDR YWHAH YWHAQ	35 interactors: AR ATXN1 ATXN1L CDK8 CREBBP ESR1 ESR2 GSK3B HNF4A ID3 KLF13 LMNA MAPK1 MAPK3 MED1 MED12 MED13 MED14 MED17 MED23 MED24 MED25 MED26 MED6 MED7 NR0B1 SIRT1 SMARCD3 SP1 SREBF2 SUMO1 TWIST2 UBE2I YY1 ZBTB7C
Entrez ID		5469	6720
HPRD ID		05055	01701
Ensembl ID		ENSG00000125686	ENSG00000072310
Uniprot IDs		Q15648	B4DEU6 P36956
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W5P 3W5Q 3W5R 3W5T	1AM9
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Response To Lipid Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Positive Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Cellular Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Developmental Process Regulation Of Cellular Response To Heat Regulation Of Cell Differentiation Organ Development Cell Differentiation Metabolic Process
Tagcloud ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Difference) ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	aberrations acly biphasic cascade chemoprevention citrate desaturase disturbed fads2 fatty harboring hbv hcc hepatocytes lipid livers lyase metabolism mtor pre remarkably s2 starting sterol subsided synchronized transgenic tumorigenesis upregulate
Tagcloud (Intersection) ?