MED1 and GJB5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MED1	GJB5
Gene Name		mediator complex subunit 1	gap junction protein, beta 5, 31.1kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Connexon Complex Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding RNA Polymerase II Transcription Cofactor Activity Chromatin Binding Transcription Cofactor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Transcription Factor Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Mediator Complex Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding LBD Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Androgen Biosynthetic Process Brain Development Lactation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Enucleate Erythrocyte Development Regulation Of Cell Cycle Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition ERK1 And ERK2 Cascade Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Receptor Activity Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Cell Communication Epidermis Development Spongiotrophoblast Differentiation Labyrinthine Layer Morphogenesis
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		42 interactors: AR BRCA1 CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MDM2 MED12 MED14 MED25 MED29 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RORA RXRA RXRB SREBF1 THRA THRB TP53 VDR YWHAH YWHAQ	5 interactors: GSK3B MED1 MYL2 PCGF2 TRIM2
Entrez ID		5469	2709
HPRD ID		05055	06840
Ensembl ID		ENSG00000125686	ENSG00000189280
Uniprot IDs		Q15648	O95377
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W5P 3W5Q 3W5R 3W5T
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Response To Steroid Hormone Cellular Response To Steroid Hormone Stimulus RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Lipid Response To Lipid Regulation Of Transcription, DNA-templated RNA Metabolic Process Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Organic Substance Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process	Organ Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Regulation Of Apoptotic Process Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Regulation Of Cell Death Cardiac Ventricle Morphogenesis Muscle Structure Development Cardiac Ventricle Development Positive Regulation Of Nucleocytoplasmic Transport Thyroid Hormone Mediated Signaling Pathway Muscle Cell Fate Specification Fat Cell Differentiation Regulation Of Epithelial Cell Differentiation Cardiac Chamber Development Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Cardiac Muscle Tissue Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Cell Death Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Hypermethylation Of CpG Island Positive Regulation Of G0 To G1 Transition Enucleate Erythrocyte Development Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Anatomical Structure Formation Involved In Morphogenesis Heart Morphogenesis Striated Muscle Cell Differentiation Depyrimidination Cellular Response To Interleukin-3 Positive Regulation Of Intracellular Transport Organ Development Regulation Of Vitamin D Receptor Signaling Pathway Mammary Gland Branching Involved In Thelarche Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Hepatocyte Proliferation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Tagcloud ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology subpopulations tgc tpbpa trophoblast
Tagcloud (Difference) ?		adam9 aurka birc5 c11orf30 ccne1 cdc6 cdh1 cpd devoid emsy esr1 fgfr1 holland ikbkb mapt mathematical meaning microdissection mlpa mrc mtdh multiplex numerical p078 prdm14 qiagen salsa top2a traf4	5and ascl2 compete connexins ctsq cx cx31 delaying derivation disparate e10 e13 gjb3 id2 junctional manifested opposed opposition pl placental placentas placentation prl3b1 spaces stereology subpopulations tgc tpbpa trophoblast
Tagcloud (Intersection) ?