POU4F1 and RIT2

Number of citations of the paper that reports this interaction (PMID 12934100)
4

Data Source:
HPRD (two hybrid, in vitro)

		POU4F1	RIT2
Gene Name		POU class 4 homeobox 1	Ras-like without CAAX 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Neuron Projection	Nucleus Plasma Membrane
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity	GTPase Activity Calmodulin Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Ventricular Compact Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Axonogenesis Synapse Assembly Mesoderm Development Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Proprioception Involved In Equilibrioception Innervation	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway
Pathways			Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)	Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-Protein Interactions		3 interactors: ESR1 EWSR1 RIT2	12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2
Entrez ID		5457	6014
HPRD ID		03379	15253
Ensembl ID		ENSG00000152192	ENSG00000152214
Uniprot IDs		Q01851	Q99578
PDB IDs
Enriched GO Terms of Interacting Partners?		Prostate Epithelial Cord Elongation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Vagina Development Uterus Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Prostate Gland Growth Cellular Response To Estradiol Stimulus Branching Involved In Prostate Gland Morphogenesis Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Cellular Response To Estrogen Stimulus Axis Elongation Androgen Metabolic Process Prostate Gland Epithelium Morphogenesis Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Prostate Gland Morphogenesis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mammary Gland Alveolus Development Mammary Gland Lobule Development Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Retinoic Acid Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Genitalia Development Positive Regulation Of Phospholipase C Activity Regulation Of Nitric Oxide Biosynthetic Process Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Mammary Gland Duct Morphogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Morphogenesis Of A Branching Structure Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Oxidoreductase Activity Maternal Process Involved In Female Pregnancy Mammary Gland Morphogenesis Regulation Of Phospholipase Activity Epithelial Cell Proliferation	Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity
Tagcloud ?		3a 3b abrogate brn cardiomyocyte cardiomyocytes fate generalised h9c2 infarct injured ischaemia ischaemic localisation localised minimise myoblasts myocardium myocyte necroptosis noxa nrvm operates puma reoxygenation rip uninjured zone	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Difference) ?		3a 3b abrogate brn cardiomyocyte cardiomyocytes fate generalised h9c2 infarct injured ischaemia ischaemic localisation localised minimise myoblasts myocardium myocyte necroptosis noxa nrvm operates puma reoxygenation rip uninjured zone	advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted
Tagcloud (Intersection) ?