RIT2 and RLF

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RIT2	RLF
Gene Name		Ras-like without CAAX 2	rearranged L-myc fusion
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane	Nucleus
	Molecular Function	GTPase Activity Calmodulin Binding GTP Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Neurotrophin TRK Receptor Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Integration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization
Pathways		Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Cognitive performance ( 19734545) Parkinson's disease ( 22451204 21738487)
Protein-Protein Interactions		12 interactors: APP CALM1 HRAS MLLT4 PLXNB3 POU4F1 RAB5A RALGDS RGL1 RLF SOS1 SRPK2	4 interactors: GCH1 PRPF40A RIT1 RIT2
Entrez ID		6014	6018
HPRD ID		15253	01614
Ensembl ID		ENSG00000152214	ENSG00000117000
Uniprot IDs		Q99578	Q13129
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Hydrolase Activity Positive Regulation Of Metabolic Process Signal Transduction Regulation Of GTPase Activity Blood Coagulation Signaling Hemostasis Cell Communication Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Cellular Response To Stimulus Small GTPase Mediated Signal Transduction Cell Development Neuron Projection Morphogenesis Intracellular Signal Transduction Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Signaling Regulation Of Cell Projection Assembly Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Neuron Projection Development Axon Guidance Positive Regulation Of Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Ras GTPase Activity Cell Differentiation Cell-cell Signaling Suckling Behavior Neuron Development Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Anatomical Structure Development Cellular Response To Fibroblast Growth Factor Stimulus Cell Morphogenesis Regulation Of Ras GTPase Activity	Olfactory Bulb Axon Guidance Striatal Medium Spiny Neuron Differentiation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Dihydrobiopterin Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tetrahydrofolate Biosynthetic Process Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Tetrahydrobiopterin Biosynthetic Process T Cell Receptor V(D)J Recombination Post-embryonic Camera-type Eye Development Keratinocyte Development Dopamine Biosynthetic Process Nitric Oxide Biosynthetic Process Striatum Development Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Forebrain Neuron Fate Commitment Catecholamine Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Keratinocyte Proliferation Tetrahydrofolate Metabolic Process Subpallium Development Small GTPase Mediated Signal Transduction Positive Regulation Of Monooxygenase Activity Response To Organic Substance Positive T Cell Selection Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dopamine Metabolic Process Nitric Oxide Metabolic Process V(D)J Recombination Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Vasodilation Pteridine-containing Compound Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Response To Pain T Cell Selection Catecholamine Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Folic Acid-containing Compound Metabolic Process Negative Regulation Of Blood Pressure Epithelial Cell Morphogenesis Pteridine-containing Compound Metabolic Process Regulation Of Cytokinesis Thymus Development Alpha-beta T Cell Differentiation
Tagcloud ?		advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted	adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse
Tagcloud (Difference) ?		advent coming cumulative deep discovered drive estimates etiology extensively familial give greatest harboring improvements loci lrrk2 mapt nominated parkinson perhaps personalized replicated scarb2 snca sporadic srebf1 ultimately variants warranted	adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse
Tagcloud (Intersection) ?