POLA1 and GINS4

Number of citations of the paper that reports this interaction (PMID 21705323)
14

Data Source:
BioGRID (pull down)

		POLA1	GINS4
Gene Name		polymerase (DNA directed), alpha 1, catalytic subunit	GINS complex subunit 4 (Sld5 homolog)
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Nuclear Matrix	Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Protein Kinase Binding Metal Ion Binding Protein Heterodimerization Activity 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Proliferation Viral Process Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	Mitotic Cell Cycle Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition G1/S-Specific Transcription Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Telomere C-strand synthesis initiation Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1	Synthesis of DNA S Phase DNA strand elongation Cell Cycle, Mitotic Unwinding of DNA
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE RB1 RBMS1 SERPINA3 SMC1A TP53 XRCC5	6 interactors: GINS1 GINS2 GINS3 POLA1 POLD1 POLE
Entrez ID		5422	84296
HPRD ID		02416	11583
Ensembl ID		ENSG00000101868	ENSG00000147536
Uniprot IDs		A6NMQ1 P09884	Q9BRT9
PDB IDs		1K0P 1K18 1N5G	2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication Chromosome Organization Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Nuclear Division Regulation Of Cell Cycle Telomere Maintenance Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Nuclear DNA Replication Mitotic DNA Integrity Checkpoint Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Mitotic Cell Cycle DNA Strand Elongation G2/M Transition Of Mitotic Cell Cycle DNA Replication Initiation Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Metabolic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination Telomere Maintenance Via Telomere Lengthening Mitotic Cell Cycle Base-excision Repair, Gap-filling Telomere Maintenance DNA Biosynthetic Process Cell Cycle DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA Recombination DNA Replication Initiation Transcription-coupled Nucleotide-excision Repair Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Base-excision Repair Nitrogen Compound Metabolic Process Nucleotide-excision Repair DNA Replication Proofreading DNA Repair Cellular Homeostasis Leading Strand Elongation G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Lagging Strand Elongation Chromosome Organization Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication, Synthesis Of RNA Primer Homeostatic Process Fatty Acid Homeostasis Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Inner Cell Mass Cell Proliferation Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process In Utero Embryonic Development
Tagcloud ?			annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised
Tagcloud (Difference) ?			annotations birc5 cdca2 cdh3 cited1 dhfr esco2 gins1 hells mc1r melana melanocyte melanocytes melk msg ncapg ncapg2 ncaph nusap1 oca2 pax3 pbk rad54l recapitulate revolutionized segregating subclasses tyms unsupervised
Tagcloud (Intersection) ?