POLA1 and RBMS1

Number of citations of the paper that reports this interaction (PMID 10869558)
4

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		POLA1	RBMS1
Gene Name		polymerase (DNA directed), alpha 1, catalytic subunit	RNA binding motif, single stranded interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Nuclear Matrix	Nucleus
	Molecular Function	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity DNA Primase Activity Protein Binding Protein Kinase Binding Metal Ion Binding Protein Heterodimerization Activity 4 Iron, 4 Sulfur Cluster Binding	Nucleotide Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Proliferation Viral Process Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process	DNA Replication RNA Processing
Pathways		Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition G1/S-Specific Transcription Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Chromosome Maintenance Telomere C-strand synthesis initiation Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs		Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS			Amyotrophic lateral sclerosis ( 19451621) Nephropathy (idiopathic membranous) ( 21323541) Type 2 diabetes ( 20418489)
Protein-Protein Interactions		17 interactors: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE RB1 RBMS1 SERPINA3 SMC1A TP53 XRCC5	2 interactors: POLA1 TFCP2
Entrez ID		5422	5937
HPRD ID		02416	03814
Ensembl ID		ENSG00000101868	ENSG00000153250
Uniprot IDs		A6NMQ1 P09884	B4DN88 P29558
PDB IDs		1K0P 1K18 1N5G	1X5O
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Replication Chromosome Organization Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle DNA-dependent DNA Replication Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Checkpoint Cellular Response To DNA Damage Stimulus Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process DNA Conformation Change Positive Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Mitotic Nuclear Division Regulation Of Cell Cycle Telomere Maintenance Cell Division Regulation Of Mitotic Cell Cycle Phase Transition Ras Protein Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Nuclear DNA Replication Mitotic DNA Integrity Checkpoint Biosynthetic Process DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Mitotic Cell Cycle DNA Strand Elongation G2/M Transition Of Mitotic Cell Cycle DNA Replication Initiation Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	Leading Strand Elongation Lagging Strand Elongation DNA Replication, Synthesis Of RNA Primer Telomere Maintenance Via Semi-conservative Replication Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Replication Initiation Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance DNA-dependent DNA Replication DNA Biosynthetic Process RNA Biosynthetic Process Double-strand Break Repair G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?			ar atherosclerosis biochemistry breed breeds build carneau celiac chief chondroitin contractile develops earliest glycolysis glycosylation inherited manipulation modeled nonesterified pathologies pigeon racer recessive representational rosiglitazone spontaneously sr unoxidized wc
Tagcloud (Difference) ?			ar atherosclerosis biochemistry breed breeds build carneau celiac chief chondroitin contractile develops earliest glycolysis glycosylation inherited manipulation modeled nonesterified pathologies pigeon racer recessive representational rosiglitazone spontaneously sr unoxidized wc
Tagcloud (Intersection) ?