ACP5 and GPC4

Number of citations of the paper that reports this interaction (PMID 12009023)
4

Data Source:
HPRD (in vivo)

		ACP5	GPC4
Gene Name		acid phosphatase 5, tartrate resistant	glypican 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Cytosol Integral Component Of Membrane Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Nucleus Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding	Heparan Sulfate Proteoglycan Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Dephosphorylation Response To Lipopolysaccharide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Superoxide Anion Generation Response To Cytokine Small Molecule Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Bone Morphogenesis	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Cell Proliferation Pathogenesis Anatomical Structure Morphogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)
Protein-Protein Interactions		11 interactors: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16	3 interactors: ACP5 COL18A1 FGF2
Entrez ID		54	2239
HPRD ID		01374	02160
Ensembl ID		ENSG00000102575
Uniprot IDs		P13686	B4E2C0 O75487
PDB IDs		1WAR 2BQ8
Enriched GO Terms of Interacting Partners?		Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Response To Organic Substance Apoptotic Mitochondrial Changes Rhombomere 5 Formation Rhombomere 3 Formation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Rhombomere 3 Morphogenesis Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Cellular Component Organization Zymogen Activation Regulation Of Signaling Brain Segmentation Regulation Of Protein Targeting To Mitochondrion Rhombomere 3 Development Rhombomere 5 Development Cellular Response To Growth Factor Stimulus Rhombomere Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of NK T Cell Differentiation DNA Recombinase Assembly JUN Phosphorylation Response To Growth Factor Cellular Response To Stimulus Positive Regulation Of Prostaglandin Biosynthetic Process Male Germ-line Stem Cell Asymmetric Division	Organ Morphogenesis Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Superoxide Anion Generation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Migration Angiogenesis Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cell Fate Specification Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Chondroblast Differentiation Riboflavin Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Inositol Phosphate Biosynthetic Process Regulation Of Satellite Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Sprouting Angiogenesis Anatomical Structure Morphogenesis Response To Hydrostatic Pressure Positive Regulation Of Endothelial Cell Apoptotic Process Blood Vessel Development Regulation Of Superoxide Anion Generation Vasculature Development Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Fibroblast Migration Endothelial Cell Morphogenesis Skeletal System Development Negative Regulation Of Nitric Oxide Biosynthetic Process Hyaluronan Catabolic Process Regulation Of Cell Migration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Cell Fate Commitment Organ Development Regulation Of Cell Motility Regulation Of Sprouting Angiogenesis Negative Regulation Of Interleukin-12 Production Regulation Of Cell Fate Specification Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Migration Involved In Sprouting Angiogenesis Response To Stress Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Positive Regulation Of Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation
Tagcloud ?		13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	ablating accepted amniotes chicken crest deliver distance dorsal gradient heparan hitch loaded migrating migratory myotome neural onto patterning player profound proteoglycan ride secreted somite somites tube whereby wnt wnts
Tagcloud (Difference) ?		13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	ablating accepted amniotes chicken crest deliver distance dorsal gradient heparan hitch loaded migrating migratory myotome neural onto patterning player profound proteoglycan ride secreted somite somites tube whereby wnt wnts
Tagcloud (Intersection) ?