ACP5 and EGR2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ACP5	EGR2
Gene Name		acid phosphatase 5, tartrate resistant	early growth response 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Cytosol Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm
	Molecular Function	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Ligase Activity Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding HMG Box Domain Binding
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Dephosphorylation Response To Lipopolysaccharide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Superoxide Anion Generation Response To Cytokine Small Molecule Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Bone Morphogenesis	Transcription From RNA Polymerase II Promoter Protein Export From Nucleus Brain Development Peripheral Nervous System Development Learning Or Memory Rhythmic Behavior Motor Neuron Axon Guidance Schwann Cell Differentiation Protein Sumoylation Facial Nerve Structural Organization Rhombomere 3 Formation Rhombomere 5 Formation Regulation Of Ossification Response To Insulin Brain Segmentation Skeletal Muscle Cell Differentiation Myelination Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuronal Synaptic Plasticity Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Multiple sclerosis (severity) ( 19010793)	Atopic dermatitis ( 23042114) Ewing sarcoma ( 22327514) Temperament ( 22832960)
Protein-Protein Interactions		11 interactors: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16	16 interactors: ACP5 BPGM HCFC1 HN1L MED31 NAB2 NDUFS2 NFATC1 RBM15B RIMKLB RPL7L1 SOX10 SOX8 SRA1 UBE2I WWP2
Entrez ID		54	1959
HPRD ID		01374	00551
Ensembl ID		ENSG00000102575	ENSG00000122877
Uniprot IDs		P13686	P11161
PDB IDs		1WAR 2BQ8
Enriched GO Terms of Interacting Partners?		Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Response To Organic Substance Apoptotic Mitochondrial Changes Rhombomere 5 Formation Rhombomere 3 Formation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Rhombomere 3 Morphogenesis Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Cellular Component Organization Zymogen Activation Regulation Of Signaling Brain Segmentation Regulation Of Protein Targeting To Mitochondrion Rhombomere 3 Development Rhombomere 5 Development Cellular Response To Growth Factor Stimulus Rhombomere Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of NK T Cell Differentiation DNA Recombinase Assembly JUN Phosphorylation Response To Growth Factor Cellular Response To Stimulus Positive Regulation Of Prostaglandin Biosynthetic Process Male Germ-line Stem Cell Asymmetric Division	Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Enteric Nervous System Development Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Peripheral Nervous System Development Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Development Heterocycle Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Mesenchymal Cell Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Metabolic Process Glial Cell Differentiation Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Mesenchyme Development Viral Process Gene Expression Nucleobase-containing Compound Metabolic Process Autonomic Nervous System Development Cellular Macromolecule Biosynthetic Process Gliogenesis Neural Crest Cell Migration Regulation Of Metabolic Process Stem Cell Development Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gliogenesis Metabolic Process Positive Regulation Of SUMO Transferase Activity Neural Crest Cell Development Stem Cell Differentiation Oligodendrocyte Differentiation Neural Crest Cell Differentiation Retinal Rod Cell Differentiation Negative Regulation Of Superoxide Anion Generation Release From Viral Latency Regulation Of Gliogenesis Renal Vesicle Induction
Tagcloud ?		13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	1beta attraction ccl2 ccl7 cd40 chemokines csf1 cxcl10 dark dendrites elongation enforced exert homer1a ht22 microglia mononuclear movement nrem phagocytes profoundly sleep somnogeneic stimulate synapses tnf vicinity wake wakefulness
Tagcloud (Difference) ?		13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	1beta attraction ccl2 ccl7 cd40 chemokines csf1 cxcl10 dark dendrites elongation enforced exert homer1a ht22 microglia mononuclear movement nrem phagocytes profoundly sleep somnogeneic stimulate synapses tnf vicinity wake wakefulness
Tagcloud (Intersection) ?