PLCB3 and PRKG2

Number of citations of the paper that reports this interaction (PMID 11278298)
9

Data Source:
HPRD (in vivo)

		PLCB3	PRKG2
Gene Name		phospholipase C, beta 3 (phosphatidylinositol-specific)	protein kinase, cGMP-dependent, type II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Protein Complex	Cytosol Apical Plasma Membrane Nuclear Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding	Protein Kinase Activity CGMP-dependent Protein Kinase Activity ATP Binding CGMP Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Protein Phosphorylation Signal Transduction Blood Coagulation Circadian Regulation Of Gene Expression Peptidyl-serine Autophosphorylation Small Molecule Metabolic Process Nitric Oxide Metabolic Process Regulation Of Nitric-oxide Synthase Activity Protein Targeting To Plasma Membrane
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	Metabolism of nitric oxide Platelet homeostasis Ca2+ pathway eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nitric oxide stimulates guanylate cyclase cGMP effects Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Height ( 19343178 23563607 18391951) HIV-1 susceptibility ( 22174851) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	6 interactors: FBXO25 LASP1 MYLK NEDD4 PLCB3 PTS
Entrez ID		5331	5593
HPRD ID		02577	09034
Ensembl ID		ENSG00000149782	ENSG00000138669
Uniprot IDs		Q01970	Q13237
PDB IDs		3OHM 4GNK
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Aorta Smooth Muscle Tissue Morphogenesis Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Tetrahydrobiopterin Biosynthetic Process Glucocorticoid Receptor Signaling Pathway Tonic Smooth Muscle Contraction Bleb Assembly Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Localization To Lysosome
Tagcloud ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4
Tagcloud (Difference) ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	adamts17 arrays besides bioinformatics bmp3 causative classic cnv cnvs duplication effort families gwas height heritable novo pappa pathogenic pathogenicity plates polygenic rodents segregating segregation short shox stature trait tulp4
Tagcloud (Intersection) ?