PLCB3 and TRPM7

Number of citations of the paper that reports this interaction (PMID 11941371)
121

Data Source:
BioGRID (pull down)

		PLCB3	TRPM7
Gene Name		phospholipase C, beta 3 (phosphatidylinositol-specific)	transient receptor potential cation channel, subfamily M, member 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Membrane Protein Complex	Ruffle Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Signal Transducer Activity Calcium Ion Binding Calmodulin Binding	Actin Binding Protein Serine/threonine Kinase Activity Calcium Channel Activity ATP Binding Myosin Binding Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Lipid Catabolic Process Intracellular Signal Transduction Inositol Phosphate Metabolic Process Small Molecule Metabolic Process	Cellular Magnesium Ion Homeostasis Calcium-dependent Cell-matrix Adhesion Actomyosin Structure Organization Ion Transmembrane Transport Protein Autophosphorylation Transmembrane Transport Necroptotic Process Calcium Ion Transmembrane Transport
Pathways		G alpha (q) signalling events Signaling by GPCR Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Integration of energy metabolism G beta:gamma signalling through PLC beta Signaling by Wnt Synthesis of IP3 and IP4 in the cytosol Gastrin-CREB signalling pathway via PKC and MAPK Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell PLC beta mediated events G-protein beta:gamma signalling Opioid Signalling Regulation of insulin secretion G-protein mediated events Activation of Kainate Receptors upon glutamate binding Inositol phosphate metabolism beta-catenin independent WNT signaling Presynaptic function of Kainate receptors G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Ca2+ pathway Free fatty acids regulate insulin secretion Transmission across Chemical Synapses	Ion channel transport TRP channels Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CALM3 CAMK2B CAMK2G FOXE1 KRIT1 PARD3 PARD6A PRKG1 PRKG2 RGS12 SLC9A3R2 TRPC3 TRPM7	9 interactors: ANXA1 EEF2 HIST3H3 MBP PLCB1 PLCB2 PLCB3 PLCG1 TRPM6
Entrez ID		5331	54822
HPRD ID		02577	10418
Ensembl ID		ENSG00000149782	ENSG00000092439
Uniprot IDs		Q01970	H0YLN8 Q96QT4
PDB IDs		3OHM 4GNK
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Protein Autophosphorylation Regulation Of Skeletal Muscle Adaptation Wound Healing Calcium Ion Transport Response To Wounding Signal Transduction Negative Regulation Of Peptidyl-threonine Phosphorylation Blood Coagulation Hemostasis Signaling Cell Communication Nitric Oxide Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Regulation Of Body Fluid Levels Phosphorylation Regulation Of Ion Transport Tight Junction Assembly Cellular Response To Stimulus Protein Phosphorylation System Development Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Heat Response To Metal Ion Nervous System Development Apical Junction Assembly Regulation Of Oxidoreductase Activity Metal Ion Transport Regulation Of Calcium Ion Transport Into Cytosol Response To Stress Pharynx Development Activation Of Meiosis Involved In Egg Activation Positive Regulation Of Calcium Ion Transport Multicellular Organismal Development Phototransduction Response To Organic Substance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Anatomical Structure Development Detection Of Light Stimulus Response To Heat Reactive Oxygen Species Metabolic Process Regulation Of Cellular Process Response To Calcium Ion Peptidyl-serine Phosphorylation Cell-cell Junction Assembly Response To Inorganic Substance Interferon-gamma-mediated Signaling Pathway	Inositol Phosphate Metabolic Process Lipid Catabolic Process Regulation Of Phospholipase Activity Alcohol Metabolic Process Cell-cell Signaling Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Synaptic Transmission Response To Cytokine Activation Of Phospholipase C Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cell Cycle Phase Transition Phospholipid Metabolic Process Positive Regulation Of Phospholipase Activity Organophosphate Metabolic Process Neutrophil Clearance Positive Regulation Of CD24 Biosynthetic Process Interleukin-15-mediated Signaling Pathway Negative Regulation Of Monocyte Extravasation Response To Interleukin-1 Positive Regulation Of Lipase Activity DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Activation Of Meiosis Involved In Egg Activation Lipid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Cytokine Production Regulation Of G1/S Transition Of Mitotic Cell Cycle Defense Response To Nematode Negative Regulation Of Phospholipase A2 Activity Interleukin-12-mediated Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Activation Of Meiosis Negative Regulation Of Interleukin-8 Secretion Response To Interleukin-12 Response To Toxic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Transport Prolactin Secretion Positive Regulation Of Acrosome Reaction Positive Regulation Of Prostaglandin Biosynthetic Process Response To Nematode Negative Regulation Of Phospholipase Activity Negative Regulation Of Cytokine Production Regulation Of Fertilization Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Response To Interleukin-15
Tagcloud ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream
Tagcloud (Difference) ?		calpain candidate candidates capn1 chuk compelling consideration defect disorder distally encode fatal harlequin hi ichq ichthyosis ikka keratinocytes locus mapping mutational narrowed phospholipase r433p refined rela scaling similarities unrelated	abundant act amount channel conserved contains controlled drastically ensure essential eukaryotes evolutionarily example frame frames influx inhibit leader magnesium mg2 open optimal provides reading regulating together translation ubiquitous upstream
Tagcloud (Intersection) ?