PFN1 and WASF1

Number of citations of the paper that reports this interaction (PMID 9843499)
143

Data Source:
HPRD (in vivo, in vitro)

		PFN1	WASF1
Gene Name		profilin 1	WAS protein family, member 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle	Cytoskeleton Actin Cytoskeleton Cell Junction SCAR Complex Synapse
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding	Actin Binding Protein Binding Protein Complex Binding Rac GTPase Binding
	Biological Process	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly	Protein Complex Assembly Movement Of Cell Or Subcellular Component Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	28 interactors: ABI1 ABL1 ACTB ACTG1 ACTR2 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A NCK1 NCKAP1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10
Entrez ID		5216	8936
HPRD ID		01452	05434
Ensembl ID		ENSG00000108518	ENSG00000112290
Uniprot IDs		P07737	Q92558
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW	3P8C
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Vesicle-mediated Transport Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Actin Cytoskeleton Organization Actin Filament-based Process Immune System Process Response To Stress Signaling Blood Coagulation Cell Communication Hemostasis Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Transport Cellular Response To Stimulus Regulation Of Body Fluid Levels Locomotion Wound Healing Cell Projection Morphogenesis Cell Part Morphogenesis Cytoskeleton Organization Cell Projection Organization Response To Stimulus Response To Wounding Axonogenesis Axon Guidance Ephrin Receptor Signaling Pathway Axon Development
Tagcloud ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Difference) ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Intersection) ?