PFN1 and RHOQ

Number of citations of the paper that reports this interaction (PMID 10445846)
12

Data Source:
HPRD (in vitro, two hybrid)

		PFN1	RHOQ
Gene Name		profilin 1	ras homolog family member Q
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Focal Adhesion Membrane Neuron Projection Synapse Extracellular Vesicular Exosome Blood Microparticle	Cytosol Actin Filament Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Actin Binding Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Rho GTPase Binding Poly(A) RNA Binding Proline-rich Region Binding	GTPase Activity Profilin Binding GTP Binding GBD Domain Binding
	Biological Process	Neural Tube Closure Platelet Degranulation Blood Coagulation Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Positive Regulation Of DNA Metabolic Process Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Cellular Response To Growth Factor Stimulus Positive Regulation Of Ruffle Assembly	Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Axon guidance Response to elevated platelet cytosolic Ca2+ Platelet degranulation Signaling by Wnt Platelet activation, signaling and aggregation Signaling by Robo receptor PCP/CE pathway beta-catenin independent WNT signaling	Rho GTPase cycle Signaling by Rho GTPases Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: ACTA1 ACTB APBB1IP C14orf1 CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH FMNL1 GPHN LRIF1 MLLT4 MYPOP NCK1 PIK3R1 RAD51 RHOQ SRPK1 STUB1 TLE1 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ	18 interactors: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL
Entrez ID		5216	23433
HPRD ID		01452	05791
Ensembl ID		ENSG00000108518
Uniprot IDs		P07737	P17081
PDB IDs		1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW	2ATX
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Actin Filament-based Process Actin Filament Organization Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Regulation Of Cellular Component Organization Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Membrane Tubulation Response To Stimulus Signaling Actin Polymerization Or Depolymerization Midbrain Development Cytoskeleton Organization Axon Guidance Movement Of Cell Or Subcellular Component Nervous System Development T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Anatomical Structure Development Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Axonogenesis System Development Cell Development Positive Regulation Of Actin Nucleation Neuron Projection Development Cellular Component Assembly Axon Development Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Immune Response Regulation Of Actin Cytoskeleton Organization Chemotaxis Positive Regulation Of Immune System Process Cell Differentiation Regulation Of Clathrin-mediated Endocytosis Locomotion	Positive Regulation Of Cell Projection Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Golgi Vesicle Budding Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Membrane Budding Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Cellular Component Size Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Small GTPase Mediated Signal Transduction Localization Within Membrane Vesicle-mediated Transport Actin Filament-based Process Positive Regulation Of Hydrolase Activity Regulation Of Cell Shape Tight Junction Assembly Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Cell Junction Assembly Regulation Of GTPase Activity Vesicle Organization Cell-cell Junction Organization Ras Protein Signal Transduction Apical Junction Assembly Organelle Organization Positive Regulation Of Rho GTPase Activity COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Organelle Organization Regulation Of Ras GTPase Activity Golgi Vesicle Transport Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Difference) ?		a20t adds aggregation als amyotrophic classic dementia demonstrating displayed e117g fatal frontotemporal hallmark heterogeneity insoluble lateral meta neurodegenerative pathology postmortem profilin published q139l rare sclerosis sequenced tar transfections variant
Tagcloud (Intersection) ?