UBR1 and TP53I3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	TP53I3
Gene Name		ubiquitin protein ligase E3 component n-recognin 1	tumor protein p53 inducible protein 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytosol	Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Leucine Binding	NADPH:quinone Reductase Activity Zinc Ion Binding Protein Homodimerization Activity Quinone Binding NADPH Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine	NADP Metabolic Process Oxidation-reduction Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBC UBE2A UBE2B	4 interactors: EEF1G FUNDC2 UBR1 UNC119
Entrez ID		197131	9540
HPRD ID		09342	05527
Ensembl ID		ENSG00000159459	ENSG00000115129
Uniprot IDs		Q8IWV7	B4DMQ7 Q53FA7
PDB IDs		3NY1	2J8Z 2OBY
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cell Cycle Process Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Cellular Localization Cellular Response To Stimulus Regulation Of Kinase Activity Establishment Of Localization In Cell Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Cell Cycle Signaling Intracellular Signal Transduction Regulation Of Catalytic Activity Cellular Response To Organic Substance Cell Communication Regulation Of Cellular Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stress Response To Radiation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Cycle Process Regulation Of Cell Death Signal Transduction Regulation Of ERBB Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cellular Protein Metabolic Process Immune System Process Histone H2A Ubiquitination Canonical Wnt Signaling Pathway Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity	Negative Regulation Of Clathrin-mediated Endocytosis Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Cytokinesis, Completion Of Separation Response To Leucine Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Regulation Of Clathrin-mediated Endocytosis Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Mitochondrion Degradation
Tagcloud ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	accumulated alters codon dozen elucidating facilitates feed forward hairpin homozygous p72 pidd pig3 pig6 polymorphism possesses preferentially prodh proline prolonged r72 shp53 subclones sumo2 transactivate triml2 tripartite variant
Tagcloud (Difference) ?		26s abruptly adducts anchoring breakdown conjugation e1 e3 e3s f1 fluctuate fos harbors heterodimeric homodimer intermediates lived multiply pathophysiological presumably reconstituted stabilizes sulfhydryl thermolabile thioester ts20 ubch5 ubiquitin ubiquitinated	accumulated alters codon dozen elucidating facilitates feed forward hairpin homozygous p72 pidd pig3 pig6 polymorphism possesses preferentially prodh proline prolonged r72 shp53 subclones sumo2 transactivate triml2 tripartite variant
Tagcloud (Intersection) ?