PDK2 and SGK1

Number of citations of the paper that reports this interaction (PMID 10191262)
114

Data Source:
HPRD (in vitro)

		PDK2	SGK1
Gene Name		pyruvate dehydrogenase kinase, isozyme 2	serum/glucocorticoid regulated kinase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Cellular Metabolic Process Small Molecule Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		10 interactors: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C
Entrez ID		5164	6446
HPRD ID		03955	04264
Ensembl ID		ENSG00000005882	ENSG00000118515
Uniprot IDs		B4DLP2 Q15119	E9PR89 O00141
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8	2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Hexose Metabolic Process Monocarboxylic Acid Metabolic Process Monosaccharide Metabolic Process Regulation Of Phosphorus Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Plasma Membrane Organic Acid Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Ion Transport Small Molecule Metabolic Process Regulation Of Establishment Of Protein Localization To Plasma Membrane Tricarboxylic Acid Cycle Positive Regulation Of Transport Citrate Metabolic Process Response To Hypoxia Regulation Of T Cell Activation Regulation Of Protein Localization To Plasma Membrane Energy Derivation By Oxidation Of Organic Compounds Regulation Of Metabolic Process Endocrine Pancreas Development Tricarboxylic Acid Metabolic Process Positive Regulation Of Transporter Activity Aerobic Respiration Regulation Of Cell-cell Adhesion Neural Plate Formation Glycogen Cell Differentiation Involved In Embryonic Placenta Development T Cell Costimulation Apoptotic Process Regulation Of Lymphocyte Activation Programmed Cell Death Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Cell Death Death Positive Regulation Of Calcium Ion Transport Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation	Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process
Tagcloud ?		addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Difference) ?		addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft	apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking
Tagcloud (Intersection) ?