SGK1 and CREB1

Number of citations of the paper that reports this interaction (PMID 15733869)
5

Data Source:
HPRD (in vivo, in vitro)

		SGK1	CREB1
Gene Name		serum/glucocorticoid regulated kinase 1	cAMP responsive element binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleus Nucleoplasm Nuclear Euchromatin ATF1-ATF4 Transcription Factor Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Enzyme Binding CAMP Response Element Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Response To Stress Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Transmembrane Transport Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Protein Phosphorylation Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Notch Signaling Pathway Synaptic Transmission Axon Guidance Lactation Memory Circadian Rhythm Regulation Of Cell Size Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Viral Process Pituitary Gland Development Secretory Granule Organization Response To Glucagon Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Drug Innate Immune Response Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization Stress-activated MAPK Cascade Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion
Pathways		Ion channel transport Stimuli-sensing channels	Signaling by the B Cell Receptor (BCR) Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling NOTCH2 intracellular domain regulates transcription Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Signaling by NOTCH2 PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions PKA-mediated phosphorylation of CREB GAB1 signalosome Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling Opioid Signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR CREB phosphorylation through the activation of CaMKK AKT phosphorylates targets in the nucleus Calmodulin induced events Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction CREB phosphorylation through the activation of CaMKII Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance CREB phosphorylation Axon guidance PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation DAG and IP3 signaling Toll Like Receptor TLR6:TLR2 Cascade CaM pathway Activated TLR4 signalling MyD88 cascade initiated on plasma membrane PI3K events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Post NMDA receptor activation events Innate Immune System Signalling by NGF PLC beta mediated events MAP kinase activation in TLR cascade Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis Signaling by FGFR Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade PLC-gamma1 signalling MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs			Adenosine monophosphate Naloxone
Diseases
GWAS		Body mass index (interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		31 interactors: BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPT MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C	75 interactors: ABL1 AKT1 ATF1 ATF6 ATF7IP ATM ATR C14orf1 CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 DYRK1A EDF1 EP300 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 MYC NR3C1 PDX1 PIAS1 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92
Entrez ID		6446	1385
HPRD ID		04264	00442
Ensembl ID		ENSG00000118515	ENSG00000118260
Uniprot IDs		E9PR89 O00141	P16220 Q53X93 Q5U0J5
PDB IDs		2R5T 3HDM 3HDN	2LXT
Enriched GO Terms of Interacting Partners?		Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Phosphatidylinositol-mediated Signaling Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Negative Regulation Of Signal Transduction Signaling Regulation Of Protein Metabolic Process Response To Stress Apoptotic Process Cell Communication Programmed Cell Death Innate Immune Response Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Response To Inorganic Substance Response To Metal Ion Response To Organic Substance Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Cellular Response To Stress Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Immune Response Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Response To Peptide Hormone Immune System Process	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Peptidyl-serine Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance Cellular Response To Stress Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Chromatin Organization Response To Stress Regulation Of Signaling Peptidyl-amino Acid Modification Regulation Of Cellular Response To Heat Organelle Organization Cell Differentiation Transcription From RNA Polymerase II Promoter
Tagcloud ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking	aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial
Tagcloud (Difference) ?		apical autophosphorylate autophosphorylation c4 cer ceramide cf cftr chloride coincidently conductance corrects cystic defect deltaf508 explants folding hypersecretion inactivates mutual pdk1 permit phosphorylates physiologically ser suppresses thr traffic trafficking	aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial
Tagcloud (Intersection) ?