PDE6D and RND1

Number of citations of the paper that reports this interaction (PMID 11980706)
39

Data Source:
HPRD (in vivo, two hybrid)

		PDE6D	RND1
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	Rho family GTPase 1
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Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Cytosol Cytoskeleton Plasma Membrane Adherens Junction
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Receptor Binding Protein Binding GTP Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Actin Filament Organization Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Axon Guidance Metabolic Process Neuron Remodeling
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	12 interactors: ARHGAP5 CREB3L2 FRS2 FRS3 GRB7 ID3 PDE6D PLXNA1 PLXNB1 PLXNB2 UBXN11 ZNF212
Entrez ID		5147	27289
HPRD ID		04056	12357
Ensembl ID		ENSG00000156973	ENSG00000172602
Uniprot IDs		O43924 Q6IB24	Q92730
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF	2CLS 2REX 3Q3J
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Semaphorin-plexin Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Organ Development Regulation Of Locomotion Neuroblast Proliferation Regulation Of Cellular Component Movement Regulation Of Rho GTPase Activity Regulation Of Rho Protein Signal Transduction Generation Of Neurons Positive Regulation Of Axonogenesis Response To Stimulus Stem Cell Proliferation Neurogenesis Tissue Development Signal Transduction Neural Precursor Cell Proliferation Epithelium Development Gland Development System Development Morphogenesis Of An Epithelium Signaling Optic Placode Formation Involved In Camera-type Eye Formation Cell Communication Regulation Of Ras GTPase Activity Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Optic Placode Formation Gland Morphogenesis Regulation Of Axonogenesis Regulation Of Cell Shape Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Cell Differentiation Nervous System Development Tissue Morphogenesis Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Catalytic Activity Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	bioinformatics colonization conversely conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	bioinformatics colonization conversely conversion cooperated deregulated derepression disrupted gap gtpase inactivates inactivation mechanistic mesenchymal neoplastic p120 plexin polarity rap1 rarely ras restrains rho signalling spontaneous suppresses turn unappreciated undifferentiated
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