PDE6D and RAB18

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDE6D	RAB18
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	RAB18, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Intracellular Golgi Apparatus Plasma Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Eye Development Intracellular Protein Transport Small GTPase Mediated Signal Transduction Brain Development Rab Protein Signal Transduction Lipid Particle Organization Endoplasmic Reticulum Tubular Network Organization
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	6 interactors: CHM PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1
Entrez ID		5147	22931
HPRD ID		04056	03731
Ensembl ID		ENSG00000156973	ENSG00000099246
Uniprot IDs		O43924 Q6IB24	B7Z4P9 B7Z5V3 Q9NP72
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF	1X3S
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-serine Dephosphorylation Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Death Death Protein Geranylgeranylation Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Regulation Of Apoptotic Process Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Death Protein Prenylation Negative Regulation Of JAK-STAT Cascade Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Apoptotic Process Involved In Morphogenesis
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	ameliorating ces copyright drives droplet esters fibrotic flux freshly gtpase helps hsc hscs immunocytochemistry insertion isoprenylation ld lxralphabeta lxrs overload phenomena profiled res reserved retards retinoid retinyl rights stellate
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	ameliorating ces copyright drives droplet esters fibrotic flux freshly gtpase helps hsc hscs immunocytochemistry insertion isoprenylation ld lxralphabeta lxrs overload phenomena profiled res reserved retards retinoid retinyl rights stellate
Tagcloud (Intersection) ?