PDE4C and SRI

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PDE4C	SRI
Gene Name		phosphodiesterase 4C, cAMP-specific	sorcin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Primary Cilium	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	CAMP Catabolic Process Signal Transduction	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: SRI	18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12
Entrez ID		5143	6717
HPRD ID		02529	01680
Ensembl ID		ENSG00000105650	ENSG00000075142
Uniprot IDs		O43849 P78505 Q08493 Q32MM7 Q7KYS4	B4DHQ6 B4DKK2 C9J0K6 P30626
PDB IDs		1LXU 2QYM	1JUO 2JC2
Enriched GO Terms of Interacting Partners?		Intracellular Sequestering Of Iron Ion Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Heart Contraction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Sequestering Of Protein Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of DNA Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Insulin Secretion Negative Regulation Of Protein Import Into Nucleus Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Positive Regulation Of Peptide Hormone Secretion Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptide Secretion Negative Regulation Of Protein Localization To Nucleus Cellular Iron Ion Homeostasis Regulation Of DNA Binding Regulation Of Striated Muscle Contraction Action Potential Negative Regulation Of Intracellular Protein Transport Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transport Negative Regulation Of Binding	Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis
Tagcloud ?			aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable
Tagcloud (Difference) ?			aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable
Tagcloud (Intersection) ?