SRI and ALG2

Number of citations of the paper that reports this interaction (PMID 12804766)
1

Data Source:
BioGRID (pull down)

		SRI	ALG2
Gene Name		sorcin	ALG2, alpha-1,3/1,6-mannosyltransferase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Vesicular Exosome	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Calcium-dependent Cysteine-type Endopeptidase Activity Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Glycolipid 6-alpha-mannosyltransferase Activity Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding
	Biological Process	Action Potential Proteolysis Transport Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Protein Glycosylation In Endoplasmic Reticulum Post-translational Protein Modification Cellular Protein Metabolic Process Response To Calcium Ion Mannosylation
Pathways		Ion channel transport Stimuli-sensing channels	Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	4 interactors: ANXA11 PEF1 PTPN23 SRI
Entrez ID		6717	85365
HPRD ID		01680	09716
Ensembl ID		ENSG00000075142
Uniprot IDs		B4DHQ6 B4DKK2 C9J0K6 P30626	Q9H553
PDB IDs		1JUO 2JC2
Enriched GO Terms of Interacting Partners?		Response To Calcium Ion Behavior Response To Metal Ion Developmental Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Muscle Contraction Response To Inorganic Substance Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Calcium Ion Transport Into Cytosol Anatomical Structure Development Striated Muscle Contraction Enzyme Linked Receptor Protein Signaling Pathway Cell Communication By Electrical Coupling Involved In Cardiac Conduction Muscle System Process Action Potential Regulation Of Membrane Potential Cell Differentiation Cellular Response To Growth Factor Stimulus Cell Communication By Electrical Coupling Cellular Calcium Ion Homeostasis Response To Growth Factor Calcium Ion Transport Calcium Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Membrane Depolarization Response To Abiotic Stimulus Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Axon Guidance Cellular Response To Catecholamine Stimulus Cellular Metal Ion Homeostasis Cell Development Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Response To Organic Substance Intracellular Signal Transduction Regulation Of Long-term Neuronal Synaptic Plasticity Immune Response Cellular Cation Homeostasis System Development Cellular Ion Homeostasis Calcium Ion Import Single-organism Behavior Membrane Depolarization During Action Potential Positive Regulation Of Metabolic Process Chemical Homeostasis Metal Ion Homeostasis	Response To Calcium Ion Regulation Of Homophilic Cell Adhesion Positive Regulation Of Homophilic Cell Adhesion Intracellular Sequestering Of Iron Ion Cytokinesis, Completion Of Separation Positive Regulation Of Intracellular Transport Positive Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proteolysis Regulation Of High Voltage-gated Calcium Channel Activity Response To Metal Ion Mitotic Cytokinetic Process Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Early Endosome To Late Endosome Transport Regulation Of Intracellular Transport Regulation Of Cell Communication By Electrical Coupling Response To Inorganic Substance Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Separation After Cytokinesis Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Cytoplasmic Sequestering Of Transcription Factor Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Heart Contraction Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Sequestering Of Protein Positive Regulation Of Adherens Junction Organization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Component Movement Positive Regulation Of Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Mitotic Cytokinesis Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of DNA Binding Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Localization
Tagcloud ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles
Tagcloud (Difference) ?		aza1r cat crabp defective differentiation embryonal hoxa indirectly inducer initiating luc mesenchymal morphological multistage parental pcc4 ra rar rars retinoic retinoid ro rxr rxre selective sr11 tk transactivates unable	aip autophagosomal bip calcineurin csa culminated cycloheximide cyclophilin cyclosporine fk506 immunosuppressant ire1alpha lacked lacuna lc3ii paraptosis paraptotic ppiase preceded redirecting resident ruled salubrinal siha tacrolimus vacuolated vacuolation vacuolations vacuoles
Tagcloud (Intersection) ?