ACTL6B and SMN1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ACTL6B	SMN1
Gene Name		actin-like 6B	survival of motor neuron 1, telomeric
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus SWI/SNF Complex NBAF Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Transcription Coactivator Activity Structural Constituent Of Cytoskeleton	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		11 interactors: ANXA7 APP CDKN1A COQ9 CSNK2B CTBP1 GSK3B PLK1 SMARCA2 SMN1 TK1	136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		51412	6606
HPRD ID		12419	02646
Ensembl ID		ENSG00000077080	ENSG00000172062
Uniprot IDs		O94805	B4DP61 Q16637
PDB IDs			1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Ketone Metabolic Process Response To Toxic Substance Developmental Process Regulation Of Protein Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Growth Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Anatomical Structure Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Phosphorylation Response To Metal Ion Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process
Tagcloud ?			atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Difference) ?			atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Intersection) ?