GP6 and FCGR3A

Number of citations of the paper that reports this interaction (PMID 10961879)
22

Data Source:
HPRD (in vivo)

		GP6	FCGR3A
Gene Name		glycoprotein VI (platelet)	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding	IgG Binding
	Biological Process	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response
Pathways		Platelet Adhesion to exposed collagen GPVI-mediated activation cascade Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25
Entrez ID		51206	2214
HPRD ID		10406	00903
Ensembl ID		ENSG00000088053	ENSG00000203747
Uniprot IDs		Q9HCN6	E9PG94 M9MML0 P08637
PDB IDs		2GI7	3AY4 3SGJ 3SGK
Enriched GO Terms of Interacting Partners?		Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Endocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Vesicle-mediated Transport Innate Immune Response Immune System Process Peptidyl-tyrosine Autophosphorylation Wound Healing Leukocyte Migration Response To Wounding Positive Regulation Of Cell Activation T Cell Costimulation Response To Stress Ephrin Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Platelet Activation Transport Protein Autophosphorylation Positive Regulation Of T Cell Activation Regulation Of Mast Cell Degranulation Positive Regulation Of Neuron Projection Development Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Homotypic Cell-cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mast Cell Activation Regulation Of Mast Cell Activation Leukocyte Mediated Immunity Cell Migration Response To External Stimulus	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis
Tagcloud ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?