FCGR3A and ZBTB25

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FCGR3A	ZBTB25
Gene Name		Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	zinc finger and BTB domain containing 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	IgG Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Immune Response	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression
Pathways		Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		15 interactors: APCS APP CD247 CD38 CD4 FCER1G FCGR1A GP6 IGHG1 LCK PTPRC SHC1 SYK ZAP70 ZBTB25	20 interactors: APIP COIL CYP2J2 DDIT3 FCGR3A HCLS1 KCTD1 KXD1 LZTS2 MAPK9 MDFI PCBD1 PNMA5 SEPHS1 SORBS3 SSX3 TNIP1 TRAF2 TSSK3 ZBTB1
Entrez ID		2214	7597
HPRD ID		00903	01926
Ensembl ID		ENSG00000203747
Uniprot IDs		E9PG94 M9MML0 P08637	P24278
PDB IDs		3AY4 3SGJ 3SGK
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cell Activation Immune Response Positive Regulation Of Immune System Process Response To Stress Cell Activation Regulation Of Cell Activation Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Platelet Activation Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion B Cell Receptor Signaling Pathway Locomotion T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation T Cell Differentiation Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Alpha-beta T Cell Proliferation Blood Coagulation Hemostasis Positive Regulation Of T Cell Differentiation Signal Transduction Lymphocyte Differentiation Leukocyte Activation Positive Regulation Of Lymphocyte Differentiation Cell Migration Regulation Of Cellular Ketone Metabolic Process Beta Selection Phagocytosis	Regulation Of Phosphorylation Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Signaling Protein Homooligomerization MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Immune System Process MRNA Transcription Toll-like Receptor Signaling Pathway Protein Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Protein Homodimerization Activity Positive Regulation Of Immune Response Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Oligomerization Regulation Of Immune System Process Regulation Of Gene Expression Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Pro-T Cell Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Cell Death Regulation Of Innate Immune Response Regulation Of Binding Positive Regulation Of Apoptotic Process
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr2b genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?