ING4 and TLX3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ING4	TLX3
Gene Name		inhibitor of growth family, member 4	T-cell leukemia homeobox 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm	Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Methylated Histone Binding	Protein Binding Sequence-specific DNA Binding
	Biological Process	DNA Replication Chromatin Organization Protein Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Growth	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription, DNA-templated Central Nervous System Development Respiratory Gaseous Exchange Negative Regulation Of Neuron Differentiation Neuron Fate Specification
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CDC34 EGLN1 EP300 HIST1H3A HIST3H3 HNRNPD HOXB9 JADE1 JADE2 KAT7 MSX1 MYC NAV2 RELA SUV39H1 TLX3 TP53	16 interactors: DENND4A GTF2A1L HIST1H2BJ HNRNPUL1 HOPX ING4 IRF9 LMO2 MEIS1 PPP1CC PQBP1 SNTA1 SP1 TLE1 TLE2 ZNF41
Entrez ID		51147	30012
HPRD ID		09774	06868
Ensembl ID		ENSG00000111653	ENSG00000164438
Uniprot IDs		Q9UNL4	O43711
PDB IDs		2K1J 2M1R 2PNX 2VNF 4AFL
Enriched GO Terms of Interacting Partners?		Chromosome Organization Chromatin Organization Histone H4-K12 Acetylation Histone H4 Acetylation Heterocycle Metabolic Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Hypoxia Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Peptidyl-lysine Modification Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Response To Oxygen Levels Histone Acetylation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Cellular Nitrogen Compound Metabolic Process Protein Acetylation Chromatin Modification Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Histone H3 Acetylation Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Macromolecule Biosynthetic Process Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Cellular Response To Nicotine Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification	Transcription, DNA-templated RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Megakaryocyte Differentiation Definitive Hemopoiesis Trophectodermal Cell Differentiation Regulation Of Cellular Process Cellular Metabolic Process Blastocyst Formation Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of Vasoconstriction By Circulating Norepinephrine Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nodal Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Blastocyst Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Peptidyl-cysteine S-nitrosylation Camera-type Eye Morphogenesis Organ Morphogenesis Notch Signaling Pathway Determination Of Left/right Asymmetry In Lateral Mesoderm Positive Regulation Of Skeletal Muscle Tissue Regeneration Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nodal Signaling Pathway Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Regulation Of Heart Contraction
Tagcloud ?		aad adenovirus adopted apparently arrested bax bcl blot caspase cleaved cne differential efect g2 measure mtt nasopharyngeal obviously overexpressed p21 pe probable regulating rgd rt survivin synergies vector western	abt alls asparaginase attractive bcl bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Difference) ?		aad adenovirus adopted apparently arrested bax blot caspase cleaved cne differential efect g2 measure mtt nasopharyngeal obviously overexpressed p21 pe probable regulating rgd rt survivin synergies vector western	abt alls asparaginase attractive bh3 challenge chemotherapeutic correspondence decreases dexamethasone doxorubicin driven exploited gradually highlights hoxa immature intensified loucy lymphoblastic mimetic mostly precursors refractory shows subtypes synergistic tal1
Tagcloud (Intersection) ?		bcl