PCM1 and E2F4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PCM1	E2F4
Gene Name		pericentriolar material 1	E2F transcription factor 4, p107/p130-binding
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Cytoplasm Centrosome Cytosol Membrane Nonmotile Primary Cilium Nuclear Membrane Centriolar Satellite Ciliary Basal Body Protein Complex	Nucleoplasm Transcription Factor Complex
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Interkinetic Nuclear Migration Cytoplasmic Microtubule Organization Microtubule Anchoring Microtubule Anchoring At Centrosome Intraciliary Transport Involved In Cilium Morphogenesis Cilium Assembly Negative Regulation Of Neurogenesis Centrosome Organization Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Maintenance	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Economic and political preferences ( 22566634)
Protein-Protein Interactions		17 interactors: ABI2 BBS4 CASK CCDC53 CEP131 CEP72 E2F4 EPS8 EXOC8 HAP1 ING5 KIAA0368 KRT15 KRT19 PCNT TTC8 YWHAQ	25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		5108	1874
HPRD ID		02624	02806
Ensembl ID		ENSG00000078674	ENSG00000205250
Uniprot IDs		A2RUU9 E7ETA6 Q15154	Q16254
PDB IDs			1CF7
Enriched GO Terms of Interacting Partners?		Organelle Organization Cilium Organization Cilium Morphogenesis Mitotic Cell Cycle Positive Regulation Of Cilium Assembly Sensory Processing Cell Cycle Process Mitotic Cell Cycle Process Cilium Assembly Cell Projection Organization Microtubule-based Process Organelle Assembly Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Projection Assembly Regulation Of Microtubule-based Movement Cellular Protein Complex Localization Rac Protein Signal Transduction Organ Development Nonmotile Primary Cilium Assembly G2/M Transition Of Mitotic Cell Cycle Cytoskeleton Organization Protein Complex Localization Anatomical Structure Development Regulation Of Cilium Assembly Positive Regulation Of Transport Positive Regulation Of Organelle Assembly Brain Development Positive Regulation Of Organelle Organization Cellular Component Assembly Head Development Regulation Of Intracellular Transport Cell Projection Morphogenesis Regulation Of Microtubule-based Process Forebrain Development Cell Part Morphogenesis Developmental Process Movement Of Cell Or Subcellular Component Olfactory Bulb Development Brain Morphogenesis Central Nervous System Development Multicellular Organismal Development Olfactory Lobe Development Eye Photoreceptor Cell Differentiation Positive Regulation Of Intracellular Transport Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Positive Regulation Of Neurotrophin Production	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication
Tagcloud ?		9p24 allogeneic asct band bcr bridging cytogenetic discovery encouraging fusion guide hematologic highlight indispensable jak1 jak2 myeloid neoplasms occurring ongoing options p22 p24 q11 rearrangements remission ruxolitinib termed usually	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Difference) ?		9p24 allogeneic asct band bcr bridging cytogenetic discovery encouraging fusion guide hematologic highlight indispensable jak1 jak2 myeloid neoplasms occurring ongoing options p22 p24 q11 rearrangements remission ruxolitinib termed usually	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Intersection) ?