E2F4 and MGA

Number of citations of the paper that reports this interaction (PMID 12748276)
36

Data Source:
BioGRID (two hybrid)

		E2F4	MGA
Gene Name		E2F transcription factor 4, p107/p130-binding	MGA, MAX dimerization protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleoplasm Transcription Factor Complex Cytoplasm MLL1 Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Dimerization Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1	8 interactors: CBX3 E2F1 E2F3 E2F4 HIST3H3 LSM8 MAX SMAD1
Entrez ID		1874	23269
HPRD ID		02806	19055
Ensembl ID		ENSG00000205250	ENSG00000174197
Uniprot IDs		Q16254	B9EGR5 Q8IWI9
PDB IDs		1CF7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Lens Fiber Cell Apoptotic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Multi-ciliated Epithelial Cell Differentiation Primary MiRNA Processing Cellular Response To Organic Substance Anoikis DNA-templated Transcription, Initiation Osteoblast Fate Commitment Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Motile Cilium Assembly Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Complex Assembly Mesodermal Cell Fate Commitment Response To Organic Substance
Tagcloud ?		adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary	absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine hrg lysis m1 m57 name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence
Tagcloud (Difference) ?		adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary	absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine hrg lysis m1 m57 name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence
Tagcloud (Intersection) ?