PAWR and RRAS2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PAWR	RRAS2
Gene Name		PRKC, apoptosis, WT1, regulator	related RAS viral (r-ras) oncogene homolog 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of B Cell Proliferation Interleukin-2 Biosynthetic Process Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		17 interactors: AATF ATP5C1 DAPK3 DRD2 FBXO45 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1	29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		5074	22800
HPRD ID		09051	02518
Ensembl ID			ENSG00000133818
Uniprot IDs		Q96IZ0	B7Z5Z2 P62070
PDB IDs		2JK9	2ERY
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Apoptotic Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Signal Transduction Negative Regulation Of Translation Apoptotic Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Response To Stimulus Cellular Metabolic Process Response To Organic Substance Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Response To Stress Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Long-term Memory Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Interleukin-4 Cellular Response To Stress Negative Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Response To Interleukin-4 Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Morphogenesis Of A Branching Structure Response To Growth Factor Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Translation In Response To Oxidative Stress	Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization
Tagcloud ?		aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Difference) ?		aggravating airway airways asthma asthmatic ats cawr coexisting expiratory fev1 forced fvc gastroesophageal gerd hz impulse ios ninety oscillometry pef plethysmography presences reflux representative sec severity tawr verified vital
Tagcloud (Intersection) ?