PAFAH1B1 and NUDC

Number of citations of the paper that reports this interaction (PMID 9601647)
26

Data Source:
HPRD (in vivo, in vitro)

		PAFAH1B1	NUDC
Gene Name		platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	nudC nuclear distribution protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Astral Microtubule Kinetochore Nuclear Envelope Centrosome Cytosol Kinesin Complex Microtubule Associated Complex Cell Cortex Axon Growth Cone Cell Leading Edge Motile Primary Cilium Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Microtubule
	Molecular Function	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Protein Homodimerization Activity Phospholipase Binding Dynein Binding Dynein Intermediate Chain Binding Phosphoprotein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Organelle Organization Microtubule-based Process Mitotic Nuclear Division Nuclear Migration Synaptic Transmission Neuroblast Proliferation Learning Or Memory Retrograde Axon Cargo Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Microtubule Organizing Center Organization Regulation Of Rho GTPase Activity Osteoclast Development Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Neuromuscular Process Controlling Balance Nuclear Envelope Disassembly Establishment Of Centrosome Localization	Mitotic Cell Cycle Mitotic Nuclear Division Multicellular Organismal Development Cell Proliferation Cell Division
Pathways		Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes	Mitotic Prometaphase Mitotic Telophase/Cytokinesis Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: CLIP1 CSNK2A1 DAB1 DCTN1 DCTN2 DCX DISC1 DNAI1 HSPH1 KARS KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D TNIK TUBA1A	5 interactors: ACD PAFAH1B1 PLK1 POT1 TINF2
Entrez ID		5048	10726
HPRD ID		03329	10122
Ensembl ID		ENSG00000007168	ENSG00000090273
Uniprot IDs		P43034	Q9Y266
PDB IDs			3QOR
Enriched GO Terms of Interacting Partners?		Microtubule-based Process Microtubule Cytoskeleton Organization Mitotic Cell Cycle Process Mitotic Nuclear Division Mitotic Cell Cycle Nervous System Development Neuron Migration Cell Cycle Process Movement Of Cell Or Subcellular Component Cytoskeleton Organization Regulation Of Neuron Projection Development Generation Of Neurons Organelle Localization Neurogenesis Microtubule Bundle Formation Cytoskeleton-dependent Intracellular Transport Cell Cycle Multicellular Organismal Development Regulation Of Cell Projection Organization System Development Establishment Of Organelle Localization Regulation Of Neuron Differentiation Organelle Organization Developmental Process Central Nervous System Development Anatomical Structure Development Regulation Of Neurogenesis Cellular Localization Brain Development G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Cell Projection Organization Head Development Cell Migration Microtubule-based Movement Regulation Of Cell Development Dendrite Development Locomotion Establishment Of Chromosome Localization Cell Motility Cell Differentiation Cerebral Cortex Development Organelle Transport Along Microtubule Neuron Projection Extension Cerebral Cortex Radially Oriented Cell Migration Regulation Of Cellular Component Organization Positive Regulation Of Neurogenesis Establishment Of Vesicle Localization Mitotic Centrosome Separation Microtubule Severing	Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Protein Localization To Chromosome Regulation Of Chromosome Organization Negative Regulation Of DNA Replication Telomere Maintenance Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Regulation Of Telomerase Activity Regulation Of Cellular Component Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of Organelle Organization Chromosome Organization Telomere Maintenance Via Telomere Lengthening Nuclear Envelope Disassembly Regulation Of DNA Biosynthetic Process Organelle Organization Positive Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Nuclear Envelope Organization Positive Regulation Of DNA Replication Protein Localization To Organelle Positive Regulation Of Transferase Activity Cellular Component Assembly Protein Localization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Microtubule Organizing Center Organization Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nucleus Organization Regulation Of Protein ADP-ribosylation Activation Of APC-Cdc20 Complex Activity Regulation Of Catalytic Activity Cellular Localization Establishment Of Centrosome Localization Telomere Formation Via Telomerase Positive Regulation Of Cellular Metabolic Process Polar Body Extrusion After Meiotic Divisions
Tagcloud ?		acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis heterozygous hippocampal homozygous implantation inactive lis1 lissencephaly migration neuronal null olfactory participates phenotypes soon thought understand	anterograde augmentation calpain chance corticogenesis dcx dilated dynein elucidations endeavoring eukaryotes example haploinsufficiency heterozygous kinesin lis1 lissencephaly microtubule microtubules migrations mnudc ndel1 neurite palmitoylation phosphorylates proteolysis retardation thick ventricles
Tagcloud (Difference) ?		acetylhydrolase alleles autonomous bulb cerebellar defects delayed developmental die disorganization display dosage embryogenesis hippocampal homozygous implantation inactive migration neuronal null olfactory participates phenotypes soon thought understand	anterograde augmentation calpain chance corticogenesis dcx dilated dynein elucidations endeavoring eukaryotes example haploinsufficiency kinesin microtubule microtubules migrations mnudc ndel1 neurite palmitoylation phosphorylates proteolysis retardation thick ventricles
Tagcloud (Intersection) ?		heterozygous lis1 lissencephaly