P4HB and PTN

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		P4HB	PTN
Gene Name		prolyl 4-hydroxylase, beta polypeptide	pleiotrophin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion Procollagen-proline 4-dioxygenase Complex Melanosome Extracellular Vesicular Exosome	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Protein Disulfide Isomerase Activity Endopeptidase Activity Procollagen-proline 4-dioxygenase Activity Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Protein Phosphatase Inhibitor Activity Growth Factor Activity Heparin Binding
	Biological Process	Response To Reactive Oxygen Species Protein Folding Proteolysis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Extracellular Matrix Organization Response To Endoplasmic Reticulum Stress Lipoprotein Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Nervous System Development Learning Positive Regulation Of Cell Proliferation Bone Mineralization Negative Regulation Of Catalytic Activity Positive Regulation Of Cell Division
Pathways		Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1L ERO1LB FEZ1 HNRNPD P4HA2 P4HA3 PRNP PTN TG UBQLN1 YWHAG	97 interactors: ACTB ALK APOBEC3G ARIH2 ARL15 ATP5C1 ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CCDC53 CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DFNA5 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GNB2L1 GPD1 GPRASP2 GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WFDC2
Entrez ID		5034	5764
HPRD ID		07181	01199
Ensembl ID		ENSG00000185624	ENSG00000105894
Uniprot IDs		B3KTQ9 B4DUA5 F5H8J2 P07237	P21246
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1
Enriched GO Terms of Interacting Partners?		4-hydroxyproline Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Protein Maturation By Protein Folding Cellular Modified Amino Acid Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Peptidyl-proline Hydroxylation Protein Hydroxylation System Development Response To Endoplasmic Reticulum Stress Developmental Process Protein Trimerization Protein Maturation Endochondral Ossification Multicellular Organismal Development Anatomical Structure Development Skin Morphogenesis Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Cellular Response To Fluoride Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Alpha-amino Acid Metabolic Process Ossification Cellular Response To Organic Substance Biomineral Tissue Development Locomotion Response To Fluoride Tooth Eruption Cellular Response To Stimulus Endochondral Bone Morphogenesis Regulation Of Cellular Protein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Stimulus Axon Guidance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Amino Acid Response To Oxidative Stress Protein Oligomerization Cell Redox Homeostasis Bone Morphogenesis	Cell Cycle Nitrogen Compound Metabolic Process Apoptotic Process Central Nervous System Development Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cell Death Regulation Of Cell Cycle Death Regulation Of Protein Catabolic Process Negative Regulation Of Transferase Activity Response To Endoplasmic Reticulum Stress Regulation Of Cell Death Regulation Of Cellular Process Signal Transduction By P53 Class Mediator Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Brain Development Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Protein Modification Process Viral Process Developmental Process Head Development Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Process Heterocycle Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Signaling Cellular Response To Stress Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	04fmolt4 04mg 09mg 28ng 32ng 37g 58vo2ml 64g 71ng 94ng 99mg backgrounds bat carioca chf corticosterone ctrl d2 depot endocrine epididymal freezing glycemia impair kg0 retroperitoneal t4 triglycerides weights
Tagcloud (Intersection) ?