P4HB and EIF2S1

Number of citations of the paper that reports this interaction (PMID 1677563)
6

Data Source:
HPRD (in vitro)

		P4HB	EIF2S1
Gene Name		prolyl 4-hydroxylase, beta polypeptide	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
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Gene Ontology Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion Procollagen-proline 4-dioxygenase Complex Melanosome Extracellular Vesicular Exosome	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Endopeptidase Activity Procollagen-proline 4-dioxygenase Activity Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Translation Initiation Factor Activity Protein Binding Ribosome Binding Poly(A) RNA Binding
	Biological Process	Response To Reactive Oxygen Species Protein Folding Proteolysis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Extracellular Matrix Organization Response To Endoplasmic Reticulum Stress Lipoprotein Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Cellular Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Translation Translational Initiation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gene Expression Endoplasmic Reticulum Unfolded Protein Response Regulation Of Translational Initiation In Response To Stress Cellular Protein Metabolic Process Protein Autophosphorylation
Pathways		Lipoprotein metabolism Hedgehog ligand biogenesis Metabolism of lipids and lipoproteins Collagen formation Chylomicron-mediated lipid transport Processing-defective Hh variants abrogate ligand secretion Detoxification of Reactive Oxygen Species Lipid digestion, mobilization, and transport Signaling by Hedgehog Collagen biosynthesis and modifying enzymes	Translation initiation complex formation Recycling of eIF2:GDP Translation L13a-mediated translational silencing of Ceruloplasmin expression Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: CD1D COL10A1 COL1A1 COL1A2 CSNK2A2 EIF2S1 ERO1L ERO1LB FEZ1 HNRNPD P4HA2 P4HA3 PRNP PTN TG UBQLN1 YWHAG	19 interactors: CASP3 CASP6 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 MELK P4HB PPP1R15A PRKCD PRKRIR SFN TERT
Entrez ID		5034	1965
HPRD ID		07181	04881
Ensembl ID		ENSG00000185624	ENSG00000134001
Uniprot IDs		B3KTQ9 B4DUA5 F5H8J2 P07237	P05198 Q53XC0
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1	1KL9 1Q8K
Enriched GO Terms of Interacting Partners?		4-hydroxyproline Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Protein Maturation By Protein Folding Cellular Modified Amino Acid Metabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Protein Heterotrimerization Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Peptidyl-proline Hydroxylation Protein Hydroxylation System Development Response To Endoplasmic Reticulum Stress Developmental Process Protein Trimerization Protein Maturation Endochondral Ossification Multicellular Organismal Development Anatomical Structure Development Skin Morphogenesis Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Cellular Response To Fluoride Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Alpha-amino Acid Metabolic Process Ossification Cellular Response To Organic Substance Biomineral Tissue Development Locomotion Response To Fluoride Tooth Eruption Cellular Response To Stimulus Endochondral Bone Morphogenesis Regulation Of Cellular Protein Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Stimulus Axon Guidance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Amino Acid Response To Oxidative Stress Protein Oligomerization Cell Redox Homeostasis Bone Morphogenesis	Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Translational Initiation Negative Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Regulation Of Translation Negative Regulation Of Translation Cellular Response To Stress Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Response To Stress Translation Translational Initiation Oligodendrocyte Development Intrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Apoptotic Process Oligodendrocyte Differentiation Protein Metabolic Process Programmed Cell Death Cellular Response To Stimulus Positive Regulation Of Hydrolase Activity Regulation Of Apoptotic Process Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Catalytic Activity Regulation Of Cell Death Glial Cell Development Response To Heat Cellular Protein Metabolic Process Response To Glucose Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Cell Death Response To Organic Substance Response To Endoplasmic Reticulum Stress Regulation Of Protein Phosphorylation Response To Stimulus Glial Cell Differentiation Positive Regulation Of Metabolic Process Response To Carbohydrate Gene Expression
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish gh1 hybrid interspecies library linkage locations loci map meiotic nf1 tp53 unresolved	atf4 atg7 cerebral contributions counteracted deprivation infarct ischemia ischemic knocking methyladenine mitophagy neuroprotection occluded ogd park2 pba protects releasing rep reperfusion rescue sensor tg thapsigargin tm tmcao transient tunicamycin
Tagcloud (Intersection) ?