NTRK3 and KIDINS220

Number of citations of the paper that reports this interaction (PMID 15167895)
29

Data Source:
HPRD (in vivo)

		NTRK3	KIDINS220
Gene Name		neurotrophic tyrosine kinase, receptor, type 3	kinase D-interacting substrate, 220kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Receptor Complex	Nucleoplasm Late Endosome Cytosol Membrane Integral Component Of Membrane Protein Complex
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding Ephrin Receptor Binding	PDZ Domain Binding
	Biological Process	Activation Of MAPK Activity Neuron Migration Negative Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Circadian Rhythm Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Modulation By Virus Of Host Transcription Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Response To Ethanol Protein Autophosphorylation Neuron Fate Specification Response To Axon Injury Positive Regulation Of Axon Extension Involved In Regeneration Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Positive Chemotaxis Response To Corticosterone Negative Regulation Of Cell Death Lens Fiber Cell Differentiation Cellular Response To Retinoic Acid Cochlea Development Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPKK Activity In Utero Embryonic Development Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus
Pathways			ARMS-mediated activation Signalling to ERKs Signalling by NGF Prolonged ERK activation events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Gaucher disease severity ( 22388998)	Neutrophil count ( 21507922)
Protein-Protein Interactions		20 interactors: APP DOK5 DYNLL1 FRS2 HTR2A IRAK1 IRAK3 JUN KIDINS220 MAPK1 MAPK3 NGFR NGFRAP1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SQSTM1	9 interactors: CDC73 CRKL MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1
Entrez ID		4916	57498
HPRD ID		01870	17235
Ensembl ID		ENSG00000140538	ENSG00000134313
Uniprot IDs		B7Z7U4 H0YND1 Q16288 Q96CY4	Q7Z322 Q9ULH0
PDB IDs		1WWC 3V5Q
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Signaling Activation Of Protein Kinase Activity Cell Communication Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transferase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Stimulus Activation Of MAPK Activity Positive Regulation Of Phosphorylation Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Immune Response-regulating Signaling Pathway Insulin Receptor Signaling Pathway Activation Of MAPKK Activity	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Cellular Response To Organic Substance Positive Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Neuron Differentiation Regulation Of Cell Proliferation Regulation Of Neuron Projection Development Response To Organic Substance Positive Regulation Of Neurogenesis Regulation Of Cell Differentiation Regulation Of Signal Transduction Circadian Rhythm Negative Regulation Of Cell Death Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Signaling Regulation Of Neuron Differentiation Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Mechanoreceptor Differentiation Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Axonogenesis Regulation Of Neurogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Phosphorylation Rhythmic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Cell Proliferation Regulation Of Fibroblast Proliferation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation
Tagcloud (Intersection) ?